Abstract： To the Editor:Primary empty sella associated with pituitary adenoma in diabetes patients is rarely reported.Here,we report a case of this association.A 63-year-old type 2 diabetic woman was admitted to our hospital on July 4,2014.Laboratory examinations revealed HbA1c level was 8.6％.General physical examination revealed typical acromegalic features of the face [Figure 1a],hands,and feet while a static enhanced magnetic resonance imaging (MRI) examination indicated an empty sella without pituitary adenoma.Laboratory examinations revealed an elevation of urine cortisol of 24 h at 353.6 μg (reference range 28.5-214.0 μg).