Preliminary Study of Brain Glucose Metabolism Changes in Patients with Lung Cancer of Different Histological Types
- Author:
- No author available
- Journal Title:
- Chinese Medical Journal
- Issue:
- 3
- DOI:
- 10.4103/0366-6999.150089
- Key Word:
- 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography;Brain Glucose Metabolism;Lung Cancer;Statistical Parametric Mapping
Abstract： Background:Cerebral glucose metabolism changes are always observed in patients suffering from malignant tumors.This preliminary study aimed to investigate the brain glucose metabolism changes in patients with lung cancer of different histological types.Methods:One hundred and twenty patients with primary untreated lung cancer,who visited People's Hospital of Zhengzhou University from February 2012 to July 2013,were divided into three groups based on histological types confirmed by biopsy or surgical pathology,which included adenocarcinoma (52 cases),squamous cell carcinoma (43 cases),and small-cell carcinoma (25 cases).The whole body 18F-fluorodeoxyglucose (1 8F-FDG) positron emission tomography (PET)/computed tomography (CT) of these cases was retrospectively studied.The brain PET data of three groups were analyzed individually using statistical parametric maps (SPM) software,with 50 age-matched and gender-matched healthy controls for comparison.Results:The brain resting glucose metabolism in all three lung cancer groups showed regional cerebral metabolic reduction.The hypo-metabolic cerebral regions were mainly distributed at the left superior and middle frontal,bilateral superior and middle temporal and inferior and middle temporal gyrus.Besides,the hypo-metabolic regions were also found in the right inferior parietal lobule and hippocampus in the small-cell carcinoma group.The area of the total hypo-metabolic cerebral regions in the small-cell carcinoma group (total voxel value 3255) was larger than those in the adenocarcinoma group (total voxel value 1217) and squamous cell carcinoma group (total voxel value 1292).Conclusions:The brain resting glucose metabolism in patients with lung cancer shows regional cerebral metabolic reduction and the brain hypo-metabolic changes are related to the histological types of lung cancer.
- [1].Treatment of depression in people with lung cancer: A systematic review[J].2013,79(1).
- [2]Stephan, Kratzer,Corinna, Mattusch,Michael W, Metzger,etc.Activation of CRH receptor type 1 expressed on glutamatergic neurons increases excitability of CA1 pyramidal neurons by the modulation of voltage-gated ion channels.[J].2013,7.
- [3]Savitz JB,Drevets WC.Imaging phenotypes of major depressive disorder: genetic correlates.[J].2009,164(1).
- [4]Hye Sook,Lee.Frontal Dysfunction Underlies Depression in Mild Cognitive Impairment: A FDG-PET Study.[J].2010,7.
- [5]M, Tashiro,K, Kubota,M, Itoh,etc.Regional cerebral glucose metabolism of patients with malignant diseases in different clinical phases.[J].1900,7.
- [6]Yoshikawa E,Furuse J,Kinoshita T,etc.Regional cerebral glucose metabolism in patients with secondary depressive episodes after fatal pancreatic cancer diagnosis.[J].2007,99(1).
- [7]Toshiro, Fujimoto,Kouzou, Takeuchi,Tetsuro, Matsumoto,etc.Metabolic changes in the brain of patients with late-onset major depression.[J].2008,164(1).
- [8]Edgar L,Rosberger Z,Levy AR,etc.Psychological distress and cancer survival: a follow-up 10 years after diagnosis.[J].2003,65(4).
- [9]Jong-Chul, Yang.Functional neuroanatomy in depressed patients with sexual dysfunction: blood oxygenation level dependent functional MR imaging.[J].1900,5.
- [10]Vos MS,Putter H,de Haes HC,etc.Denial and social and emotional outcomes in lung cancer patients: the protective effect of denial.[J].2011,72(1).
- [11]Manabu, Tashiro,Freimut D, Juengling,Ernst, Moser,etc.High social desirability and prefrontal cortical activity in cancer patients: a preliminary study.[J].2003,9.
- [12]S H, Kennedy,K R, Evans,S, Krüger,etc.Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression.[J].2001,158.
- [13]Shima Y,Akechi T,Okuyama T,etc.Major depression, adjustment disorders, and post-traumatic stress disorder in terminally ill cancer patients: associated and predictive factors.[J].2004,22(10).
- [14]Agren H,Ehnvall A,Sjogren M,etc.HPA axis activation determined by the CRH challenge test in patients with few versus multiple episodes of treatment-refractory depression.[J].2004,254(6).
- [15]Saito-Nakaya,K.,Goto,K.,Iwasaki,M.,etc.Clinical biopsychosocial risk factors for depression in lung cancer patients: A comprehensive analysis using data from the lung cancer database project[J].2012,23(8).
- [16]Endo K,Mikuni M,Ida I,etc.Brain metabolic changes associated with predispotion to onset of major depressive disorder and adjustment disorder in cancer patients--a preliminary PET study.[J].2007,41(7).
- [17]Garssen B.Psychological factors and cancer development: Evidence after 30 years of research.[J].2004,24(3).
- [18]Helene, Benveniste,Shaonan, Zhang,Ruth A, Reinsel,etc.Brain metabolomic profiles of lung cancer patients prior to treatment characterized by proton magnetic resonance spectroscopy.[J].2012,5(2).
- [19]Kubota K,Masud MM,Sasaki H,etc.Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients: a preliminary PET study.[J].2001,10(6).
- [20]O'Keane,V.,Frodl,T.,Dinan,T.G..A review of Atypical depression in relation to the course of depression and changes in HPA axis organization[J].2012,37(10).
- [21]Scheurich A,Yakushev I,Lieb K,etc.SPM-based count normalization provides excellent discrimination of mild Alzheimer's disease and amnestic mild cognitive impairment from healthy aging.[J].2009,44(1).
- [22]Campbell S,Macqueen G.The role of the hippocampus in the pathophysiology of major depression.[J].2004,29(6).
- [23]M, Tashiro,F D, Juengling,M J, Reinhardt,etc.Depressive state and regional cerebral activity in cancer patients - a preliminary study.[J].1900,7.