A novel method of defective vascular reconstruction using 2-octyl-cyanoacrylate and homemade prosthetic component
- Author:
- No author available
- Journal Title:
- Chinese Medical Journal
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.0366-6999.20132632
- Key Word:
- arteries injury;cyanoacrylate;prosthetic component;suture techniques
Abstract： Background Currently,adhesive technique is popular in vascular repair but not widely used for defective vessels.This study aimed to determine the feasibility and effectiveness of repairing defective vessels with 2-octyl-cyanoacrylate and a homemade prosthetic component.Methods Homemade prosthetic component consisting of expanded polytetrofluoroethylene (ePTFE),terylene film,and homemade soluble hollow stent mixed with adhesive can replace autologous graft and suture in repairing defective vessels,can fix vessels better using the stent without occlusive bleeding.Forty male mongrel dogs were used,20 for biomechanical tests and 20 for animal experiments.In the biomechanical test,dogs were randomly divided into two groups (n=10 each),one group repaired on the two sides of the carotid arteries with 2-octyl-cyanoacrylate and homemade component and another group repaired with suture and ePTFE.Of the 40 specimens,10 were used for adhesive and 10 for suture specimens for tension strength test,whereas the remaining specimens were used for bursting pressure test.In animal experiments,dogs were also divided into adhesive and suture groups (n=10),only of the left carotid artery.Recording the operational time,bleeding or not.Vessels were tested using color Doppler ultrasound,the inner diameter was measured,and the degree of stenosis at 8 weeks was evaluated digital subtraction angiography (DSA) were also performed.Specimens were then analyzed histologically.Results In the adhesive and suture groups,the specimens could afford atension strength of (23.80±1.51) N versus (24.60±1.08) N (P ＞0.05),the bursting pressure was (52.03±.2.43) kPa versus (50.04±3.51) kPa (P ＞0.05),and the mean time of anastomosis was (15.20±0.55) minutes versus (25.97±0.58) minutes (P ＜0.05).One dog in the adhesive group was bleeding from the suture.One dog from each group presented with thrombosis at 1 week.After measuring using ultrasound,the stenosis degree of all dogs were no more than 30％ except the two thromboses.DSA and histological observation showed no obvious difference between the two groups.Conclusion Defective vascular anastomosis with 2-octyl-cyanoacrylate and our homemade prosthetic component is feasible,effective,timesaving,and easy to master.
- [1]Omer Faik, Ersoy,Hüseyin Ayhan, Kayao?lu,Alper, Celik,etc.Comparison of cyanoacrylate-assisted arteriotomy closure with conventional closure technique.[J].2009,15(6).
- [2]M J, Timmons.Continuous sutures for microarterial end-to-side anastomoses.[J].1984,74.
- [3]Kawai F..Microbial degradation of polyethers [Review][J].2002,58(1).
- [4]Worthington G, Schenk,William D, Spotnitz,Sandra G, Burks,etc.Absorbable cyanoacrylate as a vascular hemostatic sealant: a preliminary trial.[J].2005,71(8).
- [5]Sheikh BY.Efficacy of acrylate tissue adhesive as vascular repair and hemostatic material.[J].2007,21(1).
- [6]Li Y,Zhu Y,Wei W.2-Octylcyanoacrylate-assisted microvascular anastomosis in rat orthotopic small bowel transplantation.[J].2011,27(3).
- [7]W M, Kirsch,Y H, Zhu,R A, Hardesty,etc.A new method for microvascular anastomosis: report of experimental and clinical research.[J].1992,58.
- [8]Daenens K,Schepers S,Fourneau I.Heparin-bonded ePTFE grafts compared with vein grafts in femoropopliteal and femorocrural bypasses: 1- and 2-year results.[J].2009,49(5).
- [9]Takashi Kamiji,Motomu Maeda,Koreaki Matsumoto,etc.Microvascular anastomosis using polyethylene glycol 4000 and fibrin glue[J].1989,42(1).
- [10]Bilek,M.M.,Weiss,A.S.,Wise,S.G.,etc.Plasma-based biofunctionalization of vascular implants[J].2012,7(12).
- [11]H B, Cihan,O, Gülcan,A, Hazar,etc.[Peripheral vascular injuries].[J].2001,7(2).
- [12]Baguneid MS,Goldner S,Fulford PE,etc.A comparison of para-anastomotic compliance profiles after vascular anastomosis: nonpenetrating clips versus standard sutures.[J].2001,33(4).
- [13]Clibbon JJ,Shah AK.Histoacryl(R) to secure the microvascular venous anastomosis using the coupling device.[J].2011,31(8).
- [14]Deguette A,Coste P,Fernandez P,etc.Quality control assessment of ePTFE precoating procedure for in vitro endothelial cell seeding[J].2005,26(24).
- [15]Tan KC,Ong YS,Ang ES,etc.2-Octylcynanoacrylate-assisted microvascular anastomosis in a rat model: long-term biomechanical properties and histological changes.[J].2004,24(4).
- [16]Tan LH,Ng RT,Ang ES,etc.2-Octylcyanoacrylate-Assisted Microvascular Anastomosis: Comparison with a Conventional Suture Technique in Rat Femoral Arteries.[J].2001,17(3).
- [17]van der-Want-J,van den-Dungen-JJ,van Schilfgaarde-R,etc.Nonpenetrating vascular clips for small-caliber anastomosis.[J].2000,20(3).
- [18]Y X, Chen,L E, Chen,A V, Seaber,etc.Comparison of continuous and interrupted suture techniques in microvascular anastomosis.[J].2001,26(3).