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Effect of c-Met inhibitor SU11274 on human colon cancer cell growth

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Author:
No author available
Journal Title:
Chinese Medical Journal
Issue:
14
DOI:
10.3760/cma.j.issn.0366-6999.20123619
Key Word:
colon cancer;SU11274;cell growth;c-Met

Abstract: Background Colon cancer is one of the major malignancies worldwide and it still remains resistant to much of the currently available chemotherapy.Downregulation of HGF/c-Met signaling pathway is an emerging therapy for cancer treatment.Methods In this study,the inhibitory effects of c-Met phosphorylation were observed with SU11274 on different colon cancer cell lines in vitro.Results The results revealed the significant inhibitory effects of SU 11274 on cell proliferation and cell survival,in a time and dose-dependent manner.Furthermore,the inhibitory effects of SU11274 on different subgroups of colon cancer cells via the HGF/c-Met signaling pathway were implicated in this study.Conclusion The results suggested the possible selective therapeutic effects of c-Met inhibitor on colon cancer.

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