Abstract： Background There is little information of non-perianal fistulating Crohn's disease in the consensus published by the European Crohn's and Colitis Organization in 2006 and 2010.This study was designed to demonstrate the clinical characteristics of non-perianal fistulating Crohn's disease among homogenous Chinese population.Methods One-hundred-and-eighty-four patients were retrospectively collected.All of these patients were diagnosed of Crohn's disease between February 2001 and April 2011.Results The male-to-female ratio was 2.7:1.The most common symptoms at onset were abdominal pain (88.0％),diarrhea (34.7％),and fever (28.3％).The most common disease location and behavior at diagnosis were small bowel (56.0％) and penetrating (51.6％).Among 324 non-perianal fistulae,the most common types were ileocolonic anastomotic (30.9％),terminal ileocutaneous (19.7％),and enteroenteric anastomotic (11.4％).One-hundred-and-thirty-eight (75.0％) patients received antibiotics,and β-lactam (85.5％) and metronidazole (67.4％) are most frequently used.One-hundred-and-seventy-eight (96.7％) patients suffered 514 surgical operations,and the cumulative surgical rates after 1,3,and 5 years were 38.0％,52.2％,and 58.7％ respectively.Nine patients died during the follow-up period,and the cumulative survival rates after 1,3,and 5 years were 97.8％,96.7％,and 96.2％ respectively.Conclusions This study displayed the clinical characteristics of non-perianal fistulating Crohn's disease in our center.Large population-based studies are required for further investigation in China.