Decreased regional homogeneity in major depression as revealed by resting-state functional magnetic resonance imaging
- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.0366-6999.2011.03.009
- Key Word:
- depression;first episode;functional magnetic resonance imaging;resting state;regional homogeneity
Abstract： Backgroud Functional imaging studies indicate abnormal activities in cortico-limbic network in depression during either task or resting state. The present work was to explore the abnormal spontaneous activity shown with regional homogeneity (ReHo) in depression by resting-state functional magnetic resonance imaging (fMRI).Methods Using fMRI, the differences of regional brain activity were measured in resting state in depressed vs. healthy participants. Sixteen participants firstly diagnosed with major depressive disorder and 16 controls were scanned during resting state. A novel method based on ReHo was used to detect spontaneous hemodynamic responses across the whole brain.Results ReHo in the left thalamus, left temporal lobe, left cerebellar posterior lobe, and the bilateral occipital lobe was found to be significantly decreased in depression compared to healthy controls in resting state of depression.Conclusions Abnormal spontaneous activity exists in the left thalamus, left temporal lobe, left cerebellar posterior lobe,and the bilateral occipital lobe. And the ReHo may be a potential reference in understanding the distinct brain activity in resting state of depression.
- [1]王丽,姚志剑,滕皋军,等.静息态下不同性别抑郁症患者脑功能及其差异的fMRI研究[J].2008,(4).
- [2]Olvera RL,Nicoletti M,Soares JC,etc.Medial temporal lobe abnormalities in pediatric unipolar depression.[J].2007,427(3).
- [3]Whitfield Gabrieli S,Thomason ME,Canli T,etc.Brain activation to emotional words in depressed vs healthy subjects.[J].2004,15(17).
- [4]Amit Anand,Yang Wang,Mario Dzemidzic,etc.Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression[J].2009,171(3).
- [5]Li Y,Bukhari L,Mathews VP,etc.Antidepressant effect on connectivity of the mood-regulating circuit: an FMRI study.[J].2005,30(7).
- [6]de Zwart JA,Duyn JH,Horovitz SG,etc.Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages[J].2006,24(8).
- [7]Hao Y,Liang M,Liu H,etc.Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study.[J].2006,17(1).
- [8]Mandelkern MA,Altshuler LL,Mazziotta JC,etc.Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression.[J].2005,10(5).
- [9]Wang L,Lu,Yao Z.Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study.[J].2009,115(3).
- [10]M, Hamilton.Development of a rating scale for primary depressive illness.[J].1967,6(4).
- [11]R W, Cox.AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.[J].1996,29.
- [12]Pelled G,Goelman G.Different physiological MRI noise between cortical layers.[J].2004,52(4).
- [13]Levy R,Le Bastard G,Fossati P,etc.Executive functions and updating of the contents of working memory in unipolar depression.[J].2004,38(6).
- [14]Levy R,Harvey PO,Fossati P,etc.Cognitive control and brain resources in major depression: an fMRI study using the n-back task.[J].2005,26(3).
- [15]Agarwal N,Bellani M,Perlini C,etc.Increased fronto-temporal perfusion in bipolar disorder.[J].2008,110(1/2).
- [16]Felber S,Siedentopf CM,Hofer A,etc.Gender differences in regional cerebral activity during the perception of emotion: a functional mri study.[J].2006,32(2).
- [17]Wang K,Jiang T,Zhou Y,etc.Regional homogeneity, functional connectivity and imaging markers of Alzheimer's disease: a review of resting-state fMRI studies.[J].2008,46(6).
- [18]Zang Y,Jiang T,Lu Y,etc.Regional homogeneity approach to fMRI data analysis.[J].2004,22(1).
- [19]Cowen PJ,Ploghaus A,Smith S,etc.Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression. Functional magnetic resonance imaging study.[J].2002,181(0).
- [20]Yuan Y,Zhang Z,Bai F,etc.Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study.[J].2008,111(2/3).
- [21]Paulus MP,Matthews SC,Strigo IA,etc.Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder.[J].2008,111(1).
- [22]M, Tsodyks,T, Kenet,A, Grinvald,etc.Linking spontaneous activity of single cortical neurons and the underlying functional architecture.[J].1999,286.
- [23]Keilp J,Mann JJ,Milak MS,etc.Neuroanatomic correlates of psychopathologic components of major depressive disorder.[J].2005,62(4).
- [24]Bharat Biswal,F. Zerrin Yetkin,Victor M. Haughton,etc.Functional connectivity in the motor cortex of resting human brain using echo-planar mri[J].1995,34(4).
- [25]Benkelfat C.Measurement of Brain Regional {alpha}-(11C)Methyl-L-Tryptophan Trapping as a Measure of Serotonin Synthesis in Medication-Free Patients With Major Depression.[J].2004,61(6).
- [26]Raichle ME,Raichle ME,Gusnard DA.Searching for a baseline: functional imaging and the resting human brain.[J].2001,2(10).