You Position: Home > Paper
PI-3K/Akt/GSK-3β signaling cascades stimulated by insulin like growth factor-I contribute to multiple myeloma cells proliferation and survival
( views:104, downloads:0 )
- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 14
- DOI:
- No doi available
- Key Word:
- multiple myeloma;insulin like growth factor-I;PI-3K
Abstract： @@ Multiple myeloma is characterized by the accumulation of malignant plasma cells in the bone marrow. Significant progress in molecular mechanisms of signaling pathways underlying the survival and/or proliferation of these cells has been achieved.
- [1]A C, Porter,R R, Vaillancourt.Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.[J].1998,17.
- [2]Hilbert DM,Kohler G,Rudikoff S,etc.Interleukin 6 is essential for in vivo development of B lineage neoplasms.[J].1995,182(1).
- [3]Murphy E.Inhibit GSK-3beta or there's heartbreak dead ahead.[J].2004,113(11).
- [4]G, Lattanzio,C, Libert,M, Aquilina,etc.Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice.[J].1997,151.
- [5]Laessig T,Wang X,Meintzer MK,etc.Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.[J].2000,20(24).
- [6]Jelinek DF,Witzig TE,Arendt BK.A role for insulin-like growth factor in the regulation of IL-6-responsive human myeloma cell line growth.[J].1997,159(1).
- [7]Van Zaanen,Lokhorst,Aarden,etc.Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: a phase I dose-escalating study[J].1998,102(3).
- [8]Osaki M,Oshimura M,Ito H.PI3K-Akt pathway: Its functions and alterations in human cancer[J].2004,9(6).
- [9]Marianna Pap,Geoffrey M. Cooper.Role of Translation Initiation Factor 2B in Control of Cell Survival by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Signaling Pathway[J].2002,22(2).
- [10]Brown JH,Matteo RG,Radeff Huang J,etc.G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival.[J].2004,92(5).
- [11]K C, Anderson,R M, Jones,C, Morimoto,etc.Response patterns of purified myeloma cells to hematopoietic growth factors.[J].1989,73.