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Effect of polo-like kinase 1 gene silence on cell cycle and drug resistance in K562/A02 cell
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- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 7
- DOI:
- No doi available
- Key Word:
- RNA interference;polo-like kinase 1;K562/A02;cell cycle;drug resistance
Abstract： @@ Polo-like kinase 1(PLK1) plays an important role in many cell-cycle-related events.1 At G2/M transition, PLK1 contributes to the activation of cyclinB/Cdc by phosphorylation of Cdc25C, centrosome functional maturation, bipolar spindle formation. In later stage of mitosis, PLK1 is involved in regulating components of the anaphase-promoting complex (APC) for mitotic exit and in the execution of cytokinesis.
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