ADRA2B gene insertion/deletion polymorphism and artery compliance
- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 21
- DOI:
- No doi available
- Key Word:
- large artery compliance;small artery compliance;ADRA2B gene
Abstract： Background The ADRA2B gene insertion/deletion (I/D) polymorphism is associated with various cardiovascular and metabolic phenotypes. Large (C1) and small (C2) artery compliance, assessed by pulse wave analysis, is considered as sensitive markers or risk factors for cardiovascular disease. Therefore whether the ADRA2B I/D polymorphism is associated with C1 and C2 need to be investigated. Methods A total of 227 men and 243 women were enrolled in a Chinese family-based study. C1 and C2 were measured by pulse wave analysis. ADRA2B genotypes were determined by polymerase chain reaction. Statistical methods included generalized estimation equations and quantitative transmission disequilibrium test.Results The II (31.9%), ID (46.8%) and DD (21.3%) genotype frequencies were in Hardy-Weinberg equilibrium (P=0.73). The covariates selected by stepwise regression for C1 and C2 were age, systolic pressure and gender. The population based association analysis showed that C1 and C2 were not associated with ADRA2B genotype both before (C1: P=0.28; C2: P=0.27) and after (C1: P=0.58; C2: P=0.18) the adjustment. The family-based analyses of 128 informative offspring showed that transmission of the D-allele was not associated with C1 or C2, both before (C1: P=0.42; C2: P=0.85) and after (C1: P=0.31; C2: P=0.82) the adjustment.Conclusion The study do not support that the ADRA2B gene I/D polymorphism has a major gene effect on C1 or C2 in the Chinese population of current sample size.
- [1]蒋素华,李新立,张海锋,等.α-内收蛋白基因多态性与小动脉弹性的关系研究[J].2004,(4).
- [2]张海锋,李新立,蒋素华,等.血压、动脉顺应性与颈动脉、桡动脉内膜-中层厚度关系[J].2003,(6).
- [3]Clinton T Baldwin,Faina Schwartz,Jader Baima,etc.Identification of a polymorphic glutamic acid stretch in the α2b-adrenergic receptor and lack of linkage with essential hypertension[J].1999,12(9).
- [4]Uusitupa M,Lindi V,Laakso M,etc.Effect of a three-amino acid deletion in the alpha2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects.[J].2001,25(11).
- [5]Insel PA,Rana BK,Parmer RJ,etc.Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response.[J].2005,45(6).
- [6]J N, Cohn,S, Finkelstein,G, McVeigh,etc.Noninvasive pulse wave analysis for the early detection of vascular disease.[J].1995,26.
- [7]Small KM,Brown KM,Forbes SL,etc.Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.[J].2001,276(7).
- [8]Scheinin M,Snapir A,Perola M,etc.Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.[J].2003,41(2).
- [9]Johns C,Kintsurashvili E,Ignjacev I,etc.Central alpha2B-adrenergic receptor antisense in plasmid vector prolongs reversal of salt-dependent hypertension.[J].2003,21(5).
- [10]Suzuki N,Ue H,Fukushima M,etc.alpha(2B)-Adrenergic Receptor Deletion Polymorphism Associates with Autonomic Nervous System Activity in Young Healthy Japanese.[J].2003,88(3).
- [11]Bengtsson K,Von Wowern F,Rastam L,etc.Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension.[J].2004,43(3).
- [12]Heinonen P..Identification of a Three-Amino Acid Deletion in the\u00a02B-Adrenergic Receptor That Is Associated with Reduced Basal Metabolic Rate in Obese Subjects[J].1999.
- [13]D B, Bylund.Subtypes of alpha 1- and alpha 2-adrenergic receptors.[J].1992,6.
- [14]Li X,Li Y,Zhang H,etc.Gender-specific association between pulse pressure and C-reactive protein in a Chinese population.[J].2005,19(4).
- [15]Cohn JN.Vascular wall function as a risk marker for cardiovascular disease.[J].1999,17(Suppl.5).
- [16]Link, Richard E.,Desai, Kavin.Cardiovascular regulation in mice lacking alpha2-Adrenergic receptor subtypes b and c.[J].1996,273(5276).
- [17]Makaritsis KP,Handy DE,Johns C,etc.Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension.[J].1999,33(1).
- [18]Niskanen L,Laakso M,Sivenius K,etc.A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity.[J].2003,11(8).
- [19]Kintsurashvili E,Gavras I,Johns C,etc.Effects of antisense oligodeoxynucleotide targeting of the alpha(2B)-adrenergic receptor messenger RNA in the central nervous system.[J].2001,38(5).
- [20]J W, Regan,T S, Kobilka,T L, Yang-Feng,etc.Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.[J].1988,85.