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Protective effect of cardiomyopeptidin on cultured rat hippocampal neurons injured by anoxia reoxygenation
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- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 7
- DOI:
- No doi available
- Key Word:
- cardiomyopeptidin;hippocampus;neurons;anoxia;Bcl-2
Abstract： @@ Cardiomyopeptidin (CMP), a small molecular polypeptide, is a new drug extracted from pig myocardium. Recently, evidence of its protective effect on myocardium injured by ischemia or anoxia has appeared.1,2 Neurons are also vulnerable to ischemia/anoxia. The aim of this study was to evaluate the neuroprotection of CMP in an anoxic model, which was the cultured hippocampal neurons in vitro, and to determine the relationship between CMP and expression of Bcl-2.
- [1]万华印,孔祥平,杨联萍,等.心肌肽素对缺氧-再给氧损伤心肌细胞的保护作用[J].2001,(6).
- [2]M P, Mattson,Y, Goodman,H, Luo,etc.Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.[J].1997,49.
- [3]Chen J,Graham SH,Nakayama M,etc.Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia.[J].1997,17(1).
- [4]Mattson MP,Gary DS.Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis.[J].2001,76(5).