Paper - WANFANG MED ONLINE

You Position: Home > Paper

Clinical significance of N-terminal pro-brain natriuretic peptide

( views:116, downloads:12 )

Author:: No author available

Journal Title:: CHINESE MEDICAL JOURNAL

Issue:: 11

DOI:: No doi available

Key Word:: natriuretic peptides;biological markers;biomedical research

Abstract： @@ Traditionally, it was believed that the natriuretic peptide family (NPs) was composed of four natural peptides, i.e., atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP) and urodilatin. All of them have the same 17-amino acid ring connected by bisulfate bond, which is essential for their biological activity.1 There are C-terminal and N-terminal tails on the ring. Each peptide encoded by an independent gene has its own tissue specificity and regulation mechanism. It is now suggested that beside the four traditional peptides, their precursors and the peptide fragments released by the activation or hydrolysis of the precursors, such as precursor of ANP and N-terminal proANP (NTANP), precursor of BNP and N-terminal proBNP (NTBNP) are also NPs. Furthermore, an artificially synthesized NP, vasonatrin peptide, is also a new member of NP family. In fish like eel, another peptide named ventricular natriuretic peptide was found. We now have a review on the clinical significance of NTBNP.

Reference

[1]董明清,朱妙章,于军,等.三种钠尿肽抑制大鼠肺动脉平滑肌细胞增殖效应的比较[J].2000,(3).
[2]于军,朱妙章,韦耿泽,等.血管钠肽对离体人乳内动脉的舒张作用[J].2003,(2).
[3]陈光慧,刘乃奎,Zhou AR,等.高血压相关基因（HRG-1）在心血管病发病中的作用[J].2001,(8).
[4]P. J. Hunt,A. M. Richards,M. G. Nicholls,etc.Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-PROBNP): a new marker of cardiac impairment[J].1997,47(3).
[5]Param, Maewal,James A, de Lemos.Natriuretic peptide hormone measurement in acute coronary syndromes.[J].2003,8(4).
[6]Nousiainen T,Vanninen E,Remes J,etc.Natriuretic peptides during the development of doxorubicin-induced left ventricular diastolic dysfunction.[J].2002,251(3).
[7]Cameron VA,Frampton CM,Nicholls MG,etc.Angiotensin-converting enzyme gene polymorphism interacts with left ventricular ejection fraction and brain natriuretic peptide levels to predict mortality after myocardial infarction.[J].2003,41(5).
[8]Cauza E,Hanusch Enserer U,Rosen HR,etc.Effect of gastric banding on aminoterminal pro-brain natriuretic peptide in the morbidly obese.[J].2003,11(6).
[9]Ahmadi N,Langvik TA,Smith J,etc.Radioimmunoassay for N-terminal probrain natriuretic peptide in human plasma.[J].2001,61(1).
[10]Shimizu H,Masuta K,Asada H,etc.Characterization of molecular forms of probrain natriuretic peptide in human plasma.[J].2003,334(1/2).
[11]Sleijfer DT,Dolsma WV,Meinardi MT,etc.Prospective evaluation of early cardiac damage induced by epirubicin-containing adjuvant chemotherapy and locoregional radiotherapy in breast cancer patients.[J].2001,19(10).
[12]Chirasak, Sirithunyanont,Wattana, Leowattana,Yosvi, Sukumalchantra,etc.Role of the plasma brain natriuretic peptide in differentiating patients with congestive heart failure from other diseases.[J].2003,86 Suppl 1.
[13]Urban, Alehagen,G?ran, Lindstedt,Henry, Eriksson,etc.Utility of the amino-terminal fragment of pro-brain natriuretic peptide in plasma for the evaluation of cardiac dysfunction in elderly patients in primary health care.[J].2003,49.
[14]H H, Chen,J C, Burnett.C-type natriuretic peptide: the endothelial component of the natriuretic peptide system.[J].1998,32 Suppl 3.
[15]Levin ER,Gardner DG,Samson WK.Natriuretic peptides.[J].1998,339(5).
[16]Wei Qi,Per Mathisen,John Kjekshus,etc.The effect of aortic valve replacement on N-terminal natriuretic propeptides in patients with aortic stenosis[J].2002,25(4).
[17]F D R Hobbs,A K Roalfe,J E Kenkre,etc.Reliability of N-terminal pro-brain natriuretic peptide assay in diagnosis of heart failure: cohort study in representative and high risk community populations[J].2002,324(7352).
[18]Yap LB,Holmes AM,Coghlan JG,etc.Significance of plasma N-terminal pro-brain natriuretic peptide in patients with systemic sclerosis-related pulmonary arterial hypertension.[J].2003,97(11).
[19]Nicholls MG,Yandle TG,Lainchbury JG,etc.BNP in hormone-guided treatment of heart failure.[J].2002,13(4).
[20]J HHenriksen,J PG&#248,tze,etc.Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: relation to cardiovascular dysfunction and severity of disease[J].2003,52(10).
[21]Wei C. M.,Kim C. H.,Khraibi A. A.,etc.Atrial natriuretic peptide and C-type natriuretic peptide in spontaneously hypertensive rats and their vasorelaxing actions in vitro.[J].1994.
[22]Venge P,Lindahl B,Stridsberg M,etc.N-terminal pro brain natriuretic peptide on admission for early risk stratification of patients with chest pain and no ST-segment elevation.[J].2002,40(3).
[23]Kruger C,Haass M,Haunstetter A,etc.Impact of beta-blocker treatment on the prognostic value of currently used risk predictors in congestive heart failure.[J].2002,39(10).
[24]CHARLES Christopher J.,ELLIOTT John M.,NICHOLLS M. Gary,etc.Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep[J].2003.
[25]Levy D,Wang TJ,Leip EP,etc.Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the framingham heart study.[J].2002,288(10).
[26]Baldi G,Masson S,Maggioni AP,etc.Comparative measurement of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in ambulatory patients with heart failure.[J].2002,40(8).
[27]Wattana, Leowattana,Leena, Ong-Ajyooth,Puntapong, Taruangsri,etc.Circulating N-terminal pro-brain natriuretic peptide and cardiac troponin T in chronic dialysis patients.[J].2003,86 Suppl 1.
[28]S, Talwar,I B, Squire,J E, Davies,etc.Plasma N-terminal pro-brain natriuretic peptide and the ECG in the assessment of left-ventricular systolic dysfunction in a high risk population.[J].1999,20.
[29]Peter A, McCullough,Keisha R, Sandberg.B-type natriuretic peptide and renal disease.[J].2003,8(4).
[30]Pfister R,Wielckens K,Schneider CA,etc.The value of natriuretic peptides NT-pro-BNP and BNP for the assessment of left-ventricular volume and function. A prospective study of 150 patients[J].2002,127(49).
[31]Antonio Carlos, Pereira-Barretto,Mucio Tavares, de Oliveira,Fabio Gazellato, Franco,etc.ProBNP for stratifying patients with heart failure.[J].2003,81.
[32]Quaschning, Thomas,Galle, Jan,Wanner, Christoph.Vasopeptidase inhibition: A new treatment approach for endothelial dysfunction.[J].2003,(84).
[33]M T, Rademaker,V A, Cameron,C J, Charles,etc.Neurohormones in an ovine model of compensated postinfarction left ventricular dysfunction.[J].2000,278(3).
[34]D J, Campbell,K I, Mitchelhill,S M, Schlicht,etc.Plasma amino-terminal pro-brain natriuretic peptide: a novel approach to the diagnosis of cardiac dysfunction.[J].2000,6(2).
[35]Yeo KT,Wu AH,Apple FS,etc.Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay.[J].2003,338(1).
[36]Yandle TG,Pemberton CJ,Johnson ML,etc.Deconvolution analysis of cardiac natriuretic peptides during acute volume overload.[J].2000,36(3).
[37]Hagiwara H,Takei Y,Hirose S io.titech.ac.jp.Comparative molecular biology of natriuretic peptide receptors.[J].2001,79(8).
[38]T, Sudoh,K, Kangawa,N, Minamino,etc.A new natriuretic peptide in porcine brain.[J].1988,332.
[39]Juan, Cosín Aguilar,Amparo, Hernándiz Martínez,José Luis, Díez Gil,etc.[Value of NTproBNP concentration in an out-of-hospital adult population].[J].2003,56(3).