Sensory evoked potentials in patients with affective disorders accompanying suicidal behavior
- Author:
- No author available
- Journal Title:
- CHINESE MEDICAL JOURNAL
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.0366-6999.2002.11.117
- Key Word:
- 情感障碍;诱发电位;自杀;affective disorders;evoked potentials;suicide
Abstract： Objective To investigate the variations of sensory evoked potentials (SEPs) in patients with affective disorders accompanying suicidal behavior. Methods 39 depressive patients, 22 manic patients and 33 normal controls were included in the study. Visual, auditory and somatosensory evoked potentials (VEP, AEP & SSEP) were recorded from every subject using a Nicolet Spirit Instrument. Results Both the depressive and manic groups presented prolonged latencies and decreased amplitudes of major components of SEPs as compared to that of normal controls. Depressive patients with suicidal behavior had decreased P3 amplitude of VEP (P<0.05), while maniacs with suicidal behavior had decreased P2 amplitudes of VEP & AEP (P<0.05 or 0.01). Compared with patients without suicidal behavior, patients with suicidal behavior had significantly decreased P3 amplitudes of VEP & SSEP. Conclusions The variations of SEPs in patients with affective disorders is closely associated with a history of suicidal behavior. Their clinical significance and biological correlates with suicidal behavior need further study.
- [1]D, Mück-Seler,M, Jakovljevi,N, Pivac.Platelet 5-HT concentrations and suicidal behaviour in recurrent major depression.[J].1996,39(1).
- [2]Chen Xingshi,Zhang Mingdao,Wang Jijun.Normalization of auditory evoked potential and visual evoked potential in patients with idiot savant[J].1999,(3).
- [3]C. H. Ashton,E. F. Marshall,F. Hassanyeh,etc.Biological correlates of deliberate self-harm behaviour: a study of electroencephalographic, biochemical and psychological variables in parasuicide[J].1994,90(5).
- [4]M, Hansenne,W, Pitchot,A, Gonzalez Moreno,etc.Suicidal behavior in depressive disorder: an event-related potential study.[J].1996,40(2).
- [5]W, Bligh-Glover,T N, Kolli,L, Shapiro-Kulnane,etc.The serotonin transporter in the midbrain of suicide victims with major depression.[J].2000,47(12).
- [6]Noriaki Sumi,Hisashige Nan'no,Osamu Fujimoto,etc.Interpeak latency of auditory event-related potentials (P300) in senile depression and dementia of the Alzheimer type[J].2000,54(6).
- [7]A J, Cleare.Reduced whole blood serotonin in major depression.[J].1997,5(2).
- [8]Annick Pierson,Richard Ragot,Johanna Van Hooff,etc.Heterogeneity of information-processing alterations according to dimensions of depression: An event-related potentials study[J].1996,40(2).
- [9]D H, Blackwood,L J, Whalley,J E, Christie,etc.Changes in auditory P3 event-related potential in schizophrenia and depression.[J].1987,150.
- [10]Paramala J. Santosh,Savita Malhotra,Murugeshachetty Raghunathan,etc.A study of P300 in melancholic depression-Correlation with psychotic features[J].1994,35(7).
- [11]G N, Pandey,S C, Pandey,Y, Dwivedi,etc.Platelet serotonin-2A receptors: a potential biological marker for suicidal behavior.[J].1995,152(6).