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Autoantibodies against the myocardial β1-adrenergic and M2-muscarinic receptors in patients with congestive heart failure

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Author:
No author available
Journal Title:
CHINESE MEDICAL JOURNAL
Issue:
8
DOI:
10.3760/j.issn:0366-6999.2002.08.002
Key Word:
心力衰竭;β1-受体;M2-受体;congestive heart failure;adrenrgic receptors;beta-1;cholinergic receptors

Abstract: Objective To determine whether autoantibodies against β1-adrenergic and M2-muscarinic receptors are related to patients with congestive heart failure (CHF).Methods Both synthetic peptides corresponding to amino acids sequence 197-222 and 169-173 of the second extracellular loops of the β1 and M2 receptors were used as antigens to screen sera from 265 patients. 188 were congestive heart failure (CHF) patients with different heart diseases, among them 42 were ischemic cardiomyopathy (ICD) and 52 were idiopathic dilated cardiomyopathy (IDCM),44 were hypertensive heart disease (HHD),50 were rheumatic valvular heart disease (RVHD); 77 were controls, among them 36 were simple hypertension and 41 were healthy donors (NC).Results Positive sera for β1-adrenergic receptor was found in 45.73% (86/188) of CHF patients, while in the controls it was 10.4% (8/77) (P<0.01); positive sera for M2-muscarinic receptor in CHF patients was found in 49.5% (99/188), while in the control it was 11.7% (9/77) (P<0.01). The positive ratio of autoantibodies against β1-adrenergic and M2-muscarinic receptors in CHF patients with cardiac function class Ⅱ-Ⅲ (NYHA) were significantly higher than cardiac function class Ⅳ. The average titer of autoantibodies against β1-adrenergic and M2-muscarinic receptors of the former was significantly higher than the latter; 56.1% of patients with autoantibodies against β1-adrenergic receptor had autoantibodies against M2-muscarinic receptor.Conclusions Autoantibodies against β1-adrenergic receptor and M2-muscarinic receptor were found in sera from heart failure patients with different cardiac diseases. We propose that autoantibodies against β1 and M2 receptors are not only related to the IDCM, but also to cardiac structural and functional changes.

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