You Position: Home > Paper

Transmission of the Y chromosome microdeletion to a baby boy conceived after intracytoplasmic sperm injection

( views:154, downloads:4 )
Author:
No author available
Journal Title:
CHINESE MEDICAL JOURNAL
Issue:
1
DOI:
No doi available
Key Word:
No keyword available

Abstract: @@Subfertility can be caused by acquired or genetic factors. Y chromosome microdeletion is one of the genetic factors associating with male infertility.1 Azoospermia factors (AZFa, AZFb and AZFc) have been mapped to different subregions in Yq11.2 So far, two gene families, RNA-binding motif (RBM) and deleted in azoospermia (DAZ) from interval 6, were proposed as candidate spermatogenesis genes for AZF.3,4 Recent studies demonstrated that microdeletions were detected at a frequency of 5% to 18% in the AZF region of oligospermic and azoospermic men.5-7 With the development of assisted reproductive technologies, particularly intracytoplasmic sperm injection (ICSI), these men can now father a child and the genetic abnormalities in defective spermatozoa could be transmitted to future offspring. To examine the possible transmission of the Y-chromosome microdeletion to the offspring via ICSI treatment, we performed both cytogenetic and molecular analyses of the Y chromosome on both an infertile patient with Y chromosome microdeletion and his offspring.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn