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Research progress in the regulation of islet α cell proliferation

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Author:: No author available

Journal Title:: Chinese Journal of Diabetes

Issue:: 1

DOI:: 10.3969/j.issn.1006-6187.2023.01.014

Key Word:: 胰岛α细胞;胰高血糖素;细胞增殖;糖尿病;药物治疗

Abstract：胰高血糖素(GCG)作为胰岛素拮抗调节激素,在DM发生发展中起重要作用.目前部分阻断GCG受体药物已完成T2DM患者Ⅱ期临床试验,降糖效果良好.动物研究中阻断GCG信号通路后胰岛α细胞异常增殖,靶向GCG信号通路疗效仍存争议.本文对胰岛α细胞增殖调控的研究进展进行综述.

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