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Interaction analysis of homocysteine and total bilirubin on islet β?cell function
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2023.01.011
- Key Word:
- 糖尿病,2型;总胆红素;同型半胱氨酸;交互作用
Abstract： 目的 探讨同型半胱氨酸(Hcy)和总胆红素(T-BIL)对胰岛β细胞功能的交互作用.方法 选取2018年5月至2021年4月于我院内分泌科就诊的T2DM患者242例(T2DM组),同期选取183名体检健康者为正常对照(NC)组,探讨T2DM的影响因素,分析高Hcy和低T-BIL对胰岛β细胞功能的交互作用.结果 T2DM组BMI、HbA1c、Hcy、FPG、FIns、TC、LDL-C及HOMA-IR高于NC组(P<0.05),T-BIL和HOMA-β低于NC组(P<0.05).高Hcy和低T-BIL是T2DM的影响因素.多因素Logistic回归分析显示,高Hcy、低T-BIL及二者同时存在时,胰岛β细胞功能降低的OR为1.584、1.817、7.613;OR(EF)>OR(E)+OR(F)-1,高Hcy和低T-BIL有交互作用,可进一步损伤胰岛β细胞功能.结论 高Hcy和低T-BIL对T2DM患者胰岛β细胞功能有协同交互作用,临床治疗上应重视Hcy升高及T-BIL降低,有助于保护胰岛β细胞功能.
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