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Analysis of contributions of fasting and postprandial plasma glucose of differentlevels of glycosylated hemoglobin in newly diagnosed type 2 diabetes patients
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2023.01.010
- Key Word:
- 糖尿病,2型;糖化血红蛋白;空腹血糖;餐后血糖;贡献度
Abstract： 目的 探讨新诊断T2DM患者不同HbA1c水平时FPG及餐后血糖(PPG)的贡献度.方法 选取2015年1月至2020年12月于江苏大学附属医院内分泌代谢科治疗的新诊断T2DM患者1030例.根据HbA1c水平分为HbA1c≤7.1％ 组、7.1％<HbA1c≤8.6％ 组、8.6％<HbA1c≤9.8％组、9.8％<HbA1c≤11.2％组及HbA1c>11.2％组.OGTT 5点血糖(G0、G30、G60、G120及G180)>FPG的曲线下面积(AUC)定义为AUC1,OGTT 5点血糖>6.1 mmol/L的AUC定义为AUC2.FPG对总体高血糖贡献度为(AUC2-AUC1)/AUC2×100％,PPG对总体高血糖贡献度为AUC1/AUC2×100％.结果 随着HbA1c升高,FPG贡献度逐渐升高(18.39％vs 28.96％vs 39.9％vs 45.57％vs 50.23％,P<0.01),PPG贡献度逐渐降低(81.61％vs 71.04％vs 60.10％vs 54.53％vs 49.76％,P<0.01).Pearson相关分析显示,HbA1c与G0、G30、G60、G120及G180呈正相关(P<0.01),与HOMA-β、ΔI30/ΔG30、AUCI60-120/G60-120、DI30及DI60-120呈负相关(P<0.01).结论 新诊断T2DM患者PPG对HbA1c的贡献度占主要地位,随着HbA1c升高,PPG贡献度逐渐降低,FPG贡献度逐渐升高.
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