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Correlation between remnant cholesterol and metabolic associated fatty liver disease in patients with type 2 diabetes mellitus
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2023.01.008
- Key Word:
- 糖尿病,2型;代谢相关脂肪性肝病;残余胆固醇
Abstract： 目的 探讨T2DM患者残余胆固醇(RC)与代谢相关脂肪性肝病(MAFLD)的相关性.方法 选取2020年1月至2021年12月于福建医科大学附属三明第一医院内分泌科住院治疗的976例T2DM患者,分为合并MAFLD组(MAFLD,n=563)和单纯T2DM组(T2DM,n=413).比较两组一般资料及生化指标,Logistic回归分析MAFLD的影响因素,受试者工作特征(ROC)曲线分析RC、RC联合BMI、谷丙转移酶(ALT)对MAFLD的预测价值.结果 与T2DM组比较,MAFLD组年龄、DM病程、HDL-C降低(P<0.01),BMI、SBP、DBP、FPG、TC、TG、SUA、ALT、谷草转移酶、血清白蛋白(ALB)、γ-谷氨酰转肽酶、RC升高(P<0.05或P<0.01).按照RC四分位数分组,各组MAFLD的检出率分别为34.07％、55.43％、61.13％、78.37％(P<0.01).Logistic回归分析结果显示,RC是MAFLD的影响因素.ROC曲线分析显示,RC曲线下面积(AUC)为0.688,RC联合BMI、ALT的AUC为0.788.结论 RC是T2DM患者合并MAFLD的影响因素,对MAFLD有预测价值.
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