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Changes of carotid intima?media thickness in type 2 diabetic patients with C11orf65 gene polymorphism and treated with Metformin
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2023.01.006
- Key Word:
- 糖尿病,2型;C11orf65;二甲双胍;颈动脉内膜中层厚度;基因多态性
Abstract： 目的 探讨二甲双胍治疗C11orf65基因多态性T2DM患者颈动脉内膜中层厚度(CIMT)的变化.方法 选取2020年2月至2021年8月于福建医科大学附属南平第一医院内分泌科治疗的新诊断T2DM患者282例.根据C11orf65 rs11212617基因型将二甲双胍单药治疗的T2DM患者分为CC(n=120)、CA(n=120)及AA型(n=42)共3组.收集二甲双胍治疗前后一般资料及相关指标,检测C11orf65基因型多态性、HbA1c、CIMT等.结果 282例患者基因型分布符合Hardy-Weinberg遗传平衡.二甲双胍治疗后CC基因型低于CA、AA基因型[(1.43±0.65)vs(1.64±0.66)vs(1.65±0.67)mm,P<0.05].多因素线性回归分析结果显示,C11orf65基因型多态性是二甲双胍治疗前后CIMT变化的影响因素.结论 T2DM患者C11orf65基因多态性影响二甲双胍调控血糖,与动脉粥样硬化相关.
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