You Position: Home > Paper
Association of UCP1 Gene?3826A>G polymorphism with type 2 diabetes mellitus in Dali,Yunnan province
( views:11, downloads:11 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2023.01.005
- Key Word:
- 解偶联蛋白1;基因多态性;基因型;糖尿病,2型
Abstract： 目的 探讨解偶联蛋白1(UCP1)基因-3826 A>G位点多态性与云南大理地区T2DM患病率的相关性.方法 选取2021年1～12月于大理大学第一附属医院内分泌科收治的204例T2DM患者(T2DM组),同期选取174名体检健康者为正常对照(NC)组,收集两组一般资料和生化指标,采用竞争性等位基因特异性PCR(KASP)对UCP1基因-3826 A>G位点进行基因分型并统计分析.结果 T2DM、NC组UCP1基因-3826 A>G位点基因型均符合Hardy-Weinberg遗传平衡(P>0.05).T2DM组AG、GG基因型频率和G等位基因频率高于NC组.AG、GG基因型和G等位基因可增加T2DM风险1.638、2.109和1.386倍.T2DM患者AG和GG基因型BMI高于AA基因型(P<0.05).结论 UCP1基因-3826 A>G位点多态性与云南大理地区T2DM相关,且该基因位点突变增加T2DM风险.
- [1]苏银霞,马艳,姚华,等.维吾尔族2型糖尿病与锌转运蛋白-8基因单核苷酸多态性及其交互作用的相关性分析[J].2016,(1).
- [2]肖新怀,陈澍,苏丽芳,等.广州市汉族2型糖尿病患者解耦联蛋白1基因3826 A/G多态性分析[J].2017,(30).
- [3]B, Kie?-Wilk,I, Wybrańska,M, Malczewska-Malec,etc.Correlation of the -3826A>G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland.[J].2002,53.
- [4]Zimmet, Paul,Shi, Zumin,El-Osta, Assam,etc.Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine[J].2018,14(12).
- [5]Shahanas,Chathoth,Mona H,Ismail,Chittibabu,Vatte,etc.Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study.[J].2018,19(1).
- [6]梁伟,朱丽君,段滢,等.TCF7L2基因rs7903146多态性与2型糖尿病关系的Meta分析[J].2016,(5).
- [7]Fukuyama K,Ohara T,Hirota Y,etc.Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes.[J].2006,339(4).
- [8].PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-β/δ and PPAR-γ.[J].2017,13(3).
- [9]Kim KS,Cho DY,Kim YJ,etc.The finding of new genetic polymorphism of UCP-1 A-1766G and its effects on body fat accumulation[J].2005,1741(1/2).
- [10]Carey E. Lyons,Maria Razzoli,Erin Larson,etc.Optogenetic‐induced sympathetic neuromodulation of brown adipose tissue thermogenesis[J].2020,34(2).
- [11]Lim, Jisun,Park, Hye Soon,Kim, Jimin,etc.Depot-specific UCP1 expression in human white adipose tissue and its association with obesity-related markers[J].2020,44(3).
- [12]Nicoletti, Carolina Ferreira,Rus Perez de Oliveira, Ana Paula,Franco Brochado, Maria Jose,etc.UCP1-3826 A > G polymorphism affects weight, fat mass, and risk of type 2 diabetes mellitus in grade III obese patients[J].2016,32(1).
- [13].Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs[J].2020,25(1987).
- [14]He Sun,Jun-Ting Zhang,Xue-Rong Xie,etc.Association of uncoupling protein gene polymorphisms with essential hypertension in a northeastern Han Chinese population[J].2019,33(7).
- [15]Marcelin, Genevieve,Silveira, Ana Leticia M.,Martins, Lais Bhering,etc.Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis[J].2019,129(10).
- [16]Hu, Frank B.,Ley, Sylvia H.,Zheng, Yan.Global aetiology and epidemiology of type 2 diabetes mellitus and its complications[J].2018,14(2).
- [17]Wang Y,Willett WC,Rimm EB,etc.Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men.[J].2005,81(3).
- [18]McAdams MA,Van-Dam RM,Hu FB.Comparison of self-reported and measured BMI as correlates of disease markers in US adults.[J].2007,15(1).