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Expression and clinical significance of hsa_circ_0071336 in peripheral blood of patients with type 2 diabetes mellitus
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2023.01.003
- Key Word:
- 环状RNA;糖尿病,2型;空腹血糖受损;胰岛素抵抗
Abstract： 目的 探讨T2DM患者外周血hsa_circ_0071336表达及临床意义.方法 选取2017年5月至2019年8月于首都医科大学附属宣武医院就诊的89例新诊断T2DM患者(T2DM组)、76例IFG患者(IFG组)及83名同期体检健康者(NC组),分析各组hsa_circ_0071336表达水平与糖代谢指标的相关性.采用多元线性回归和Logistic回归分析IR、T2DM和IFG的影响因素.受试者工作特征(ROC)曲线评价hsa_circ_0071336对鉴别T2DM和IFG的程度.结果 T2DM组BMI、腰高比、WC,SBP、DBP,FPG、HbA1c、FIns、TG、LDL-C,HOMA-IR、TyG、Mets-IR高于NC组(P<0.05),APN低于NC、IFG组(P<0.05).Spearman相关分析显示,hsa_circ_0071336表达水平与APN呈正相关(P<0.05),与FPG、HbA1c、FIns呈负相关(P<0.05).多元线性回归分析和Logistic回归分析结果显示,hsa_circ_0071336是IR、T2DM和IFG的影响因素,联合传统危险因素鉴别T2DM和IFG的ROC曲线下面积为0.865、0.743.结论 T2DM患者外周血hsa_circ_0071336表达降低,可作为T2DM潜在生物标志物.
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