Measurement of retinal nerve fiber layer thickness in patients with type 2 diabetes mellitus and its correlation with homocysteine
- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1006⁃6187.2022.11.005
- Key Word:
- 糖尿病,2型;糖尿病视网膜病变;视网膜神经纤维层;同型半胱氨酸
Abstract： 目的 探讨T2DM患者视网膜神经纤维层(RNFL)厚度与同型半胱氨酸(HCY)的相关性.方法 选取2016年8月至2020年8月于北京顺义空港医院内分泌科诊断为T2DM患者582例1164眼,另选取同期于我院体检及眼科就诊的健康者176例342眼为正常对照(NC)组.根据荧光素眼底血管造影(FFA)结果分为DR临床前期组(NDR组)、非增生期DR组(NPDR组)、增生期DR组(PDR组).应用光学相干断层扫描(OCT)测量受试者视网膜上方、下方、颞侧、鼻侧及全周360°RNFL厚度.结果 与NC组比较,其他三组DM病程、FPG、HbA1c升高(P<0.05),NDR组上方平均值(SA)、全周360°RNFL平均厚度(mean360°)降低(P<0.05),NPDR组SA、下方平均值(IA)、鼻侧平均值(NA)、mean360°降低(P<0.05),PDR组SA、IA、NA、颞侧平均值(TA)、mean360°升高(P<0.05).与NDR组比较,PDR组DM病程、FPG、UAlb、HCY、TG、SA升高(P<0.05),IA、mean360°降低(P<0.05).与NPDR组比较,PDR组DM病程、FPG、UAlb、HCY、TG、SA、IA、NA、TA、mean360°升高(P<0.05).Pearson相关分析显示,RNFL厚度与SUA呈正相关(P<0.05),与年龄、DM病程、HCY呈负相关(P<0.05).多元线性回归分析显示,DM病程是RNFL厚度的影响因素.结论 在DR非增生期,随着病变加重,RNFL厚度逐渐变薄,与HCY升高相关,在DR增生期,RNFL厚度增厚,RNFL厚度可早期监测DR.
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