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Association analysis between serum uric acid levels and diabetic retinopathy among patients with type 2 diabetes mellitus
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1006⁃6187.2022.11.001
- Key Word:
- 血尿酸;糖尿病视网膜病变;糖尿病,2型
Abstract： 目的 探讨T2DM患者血尿酸(SUA)与DR的相关性.方法 选取2010年1月至2020年1月于大连市中心医院内分泌科住院治疗的T2DM患者1344例.根据基线SUA四分位间距分为Q1、Q2、Q3及Q4组.Cox回归分析DR进展的影响因素,受试者工作特征(ROC)曲线分析SUA对DR进展的预测价值.结果 中位随访时间4.75年,228(16.9％)例患者出现DR进展.Cox回归分析结果显示,Q3、Q4组DR进展风险比分别为Q1组的1.462、1.928倍(P<0.05),DM病程、SBP、HbA1c是DR进展的危险因素.分层分析结果显示,SUA与DR进展风险不受DM病程、SBP和HbA1c影响.SUA预测DR进展的ROC曲线下面积为0.725,最佳临界值为295.5μmol/L.结论 T2DM患者SUA是DR进展的独立危险因素,检测SUA对预测DR进展有一定价值.
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