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The role of preimplantation genetic testing for aneuploidy in the treatment of infertility with AZFc microdeletion on Y chromosome

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Author:
No author available
Journal Title:
China Clinical Practical Medicine
Issue:
4
DOI:
10.3760/cma.j.cn115570-20220328-00637
Key Word:
AZFc微缺失;胚胎植入前非整倍体检测;卵胞浆内单精子注射技术;高通量测序技术;体外受精-胚胎移植;AZFc microdeletion;Preimplantation genetic testing for aneuploidy;Intracytoplasmic sperm injection;Next-generation sequencing technology;In vitro fert

Abstract: Objective:To analyze the role of preimplantation genetic testing for aneuploidy(PGT-A) on assisted pregnancy therapy in AZFc microdeletion infertile patients.Methods:This study was a retrospective study, a total of 56 male patients with infertility caused by AZFc microdeletion of Y chromosome chose in vitro fertilization embryo transfer(IVF-ET) technology for assisted pregnancy treatment in the department of reproductive medicine of the northern theater general hospital from November 2015 to December 2020.The age of husbands were(34.22±4.15) years old, ranging from 26 to 43 years old, the age of the spouses were(32.93±3.91 )years old, ranging from 27 to 41 years old.After full communication, all patients were divided into PGT-A group( n=31) and morphological group( n=25) according to the wishes of patients.PGT-A group selected embryos for transplantation according to the results of PGT-A based on high-throughput sequencing; Patients in the morphological group chose to select embryos for fresh transfer or resuscitation transfer according to morphology.The status of transplantation, pregnancy rate, live birth rate of transplantation cycles, the proportion of couples holding babies and the success rate of single embryo transplantation were compared between the two groups. Results:A total of 22 patients in the morphological group entered the transplantation cycle, 29 transplantation cycles, 54 embryos were transplanted, 14 transplantation cycles entered the pregnancy stage, 10 transplantation cycles obtained live births, 6 male fetuses and 5 female fetuses(including 1 twins). In PGT-A group, 21 patients entered the transfer cycle, 21 embryos were transferred in 21 transfer cycles, and 18 transfer cycles entered the pregnancy stage, 15 transfer cycles obtained live births, 1 male fetus, 15 female fetuses(including 1 twins). The number of transfer cycles and the number of transferred embryos in morphological group were higher than those in PGT-A group, and the difference was statistically significant( P<0.05). The clinical pregnancy rate[85.7%(18/21)], the proportion of couples holding babies[48.4%(15/31)]and the success rate of single embryo transfer[71.4%(15/21)]in PGT-A group were higher than those in morphological group[48.3%(14/29), 40.0%(10/25), 18.5%(10/54)], and the difference was statistically significant( P<0.05). Conclusions:PGT-A can significantly reduce the number of transplants without affecting the chances of patients to obtain offspring and can effectively help patients to obtain offspring without reproductive risk.

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