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Analysis of human papilloma virus infection status and its influencing factors

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Author:
No author available
Journal Title:
China Clinical Practical Medicine
Issue:
2
DOI:
10.3760/cma.j.cn115570-20211223-03942
Key Word:
人乳头状病毒;阴道微生态;宫颈癌;妊娠;Human papilloma virus;Vaginal microecology;Uterine cervical carcinoma;Pregnancy

Abstract´╝Ü Objective:The status of human papilloma virus(HPV)infection and its influencing factors were analyzed by examining the vaginal microecology and HPV infection in women.Methods:This study was a retrospective study, 3 373 women(1 141 pregnant women and 2 232 non pregnant women)were selected from the gynecology and obstetrics clinic of Jinshan Branch of Shanghai Sixth People′s Hospital from January 2020 to March 2021, aged(37.17±12.19)years old, ranging from 15 to 88 years old.All the recruited participants received HPV genotypes test of cervical exfoliated cells and vaginal microecology test of vaginal secretions at the same time.Tested the microecology of vaginal secretions and HPV genotypes of cervical exfoliated cells, analyze the distribution of HPV genotypes and the infection rate of high-risk HPV in pregnant women and non pregnant women, analyze the relationship and influence between age, vaginal microecological changes and HPV infection, and analyze the relationship and influence between pregnancy, age, vaginal microecological changes and high-risk HPV infection.Results:The common subtypes of HPV in pregnant women were 52, 16, 68 and 58, and the common subtypes of HPV in non pregnant women were 16, 52, 58 and 68, all of which were high-risk types.Both pregnant women and non pregnant women were mainly infected with single high-risk HPV.The HPV infection rate of pregnant women[25.59%(292/1 411)]was lower than that of non pregnant women[33.33%(744/2 232)], and the difference was statistically significant( P<0.05).There were significant differences in age, pH, hydrogen peroxide, sialidase and Trichomonas between HPV positive and negative( P<0.05).Logistic regression analysis showed that age, hydrogen peroxide and sialidase had an effect on HPV infection, leukocyte esterase[68.30%(599/877)]in high-risk group was higher than that in low-risk group[59.75%(95/159)], and the difference was statistically significant( P<0.05).Logistic regression analysis showed that high-risk HPV infection was not related to pregnancy, age and vaginal microecological changes, and the differences were not statistically significant( P>0.05). Conclusions:High-risk types were mainly found among the patients with HPV infection.Patients with abnormal vaginal microecology(positive for hydrogen peroxide and sialidase)were more likely to be infected with HPV.Pregnancy, age and vaginal microecology changes had no affect the infection of high-risk HPV.

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