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Exploring the clinical therapeutic effect and safety of non-invasive ventilator combined with oxygen-driven nebulization inhalation in the treatment of chronic obstructive pulmonary disease with respiratory failure

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Author:
No author available
Journal Title:
China Clinical Practical Medicine
Issue:
4
DOI:
10.3760/cma.j.cn115570-20210630.01930
Key Word:
无创呼吸机;氧气雾化吸入;慢性阻塞性肺疾病;呼吸衰竭;Non-invasive ventilator;Oxygen atomization inhalation;Chronic obstructive pulmonary disease;Respiratory failure

Abstract: Objective:To explore and analyze the clinical efficacy and safety of non-invasive ventilator combined with oxygen-driven nebulization inhalation in the treatment of chronic obstructive pulmonary disease( COPD )with respiratory failure.Methods:Select the department of Respiratory and Critical Care Medicine of Tengzhou Central People′s Hospital from June 2018 to June 2021 the 90 patients with COPD complicated with respiratory failure were admitted, 49 males and 41 females, aged(58.3±4.1)years old, and the age range was 49 to 72 years old.The patients were randomly divided into non-invasive breathing machine and nebulization treatment groups by random number table method, with 45 cases in each group.The non-invasive breathing unit is treated with a non-invasive ventilator, and the nebulization treatment group is combined with oxygen-driven nebulization on the basis of the non-invasive breathing unit.The blood gas analysis(oxygen partial pressure, carbon dioxide partial pressure, oxygen saturation), lungs and lungs are compared between the two groups before and after treatment.Functional indicators[forced vital capacity(FVC), forced expiratory volume in the first second(FEV 1), FEV 1/FVC, mechanical ventilation rate of tracheal intubation , Average length of hospital stay, fatality rate and serum procalcitonin levels before and after treatment, and compare the occurrence of adverse reactions. Results:After treatment, the partial pressure of oxygen[(85.11±9.21)mmHg, 1 mmHg=0.133 kPa]in the nebulization treatment group was higher than that of the non-invasive breathing unit[(74.23±8.95)mmHg]and the partial pressure of carbon dioxide[(41.13±4.47)mmHg]lower than non-invasive breathing unit[(50.32±3.31)mmHg], oxygen saturation[(93.21±6.10)%]higher than non-invasive breathing unit[(88.74±11.25)%], FEV 1[(1.64±0.75)L], FVC[(1.98±0.41)L], FEV 1/FVC(72.33±7.25)is higher than non-invasive breathing machine[(1.06±0.57)L, (1.66±0.24)L, (55.36±6.65)], the mechanical ventilation rate of tracheal intubation[6.7%(3/45)]lower than non-invasive breathing machine[20.0%(9/45)], average hospital stay[(10.96±4.52)d]lower than non-invasive breathing machine[(20.23±4.69)d], serum Procalcitonin[(0.13±0.11)μg/L]was lower than that of non-invasive breathing unit[(0.36±0.20)μg/L], the difference was statistically significant( P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups of patients during treatment( P>0.05). Conclusion:Non-invasive ventilator plus oxygen atomization drive treatment of COPD combined with respiratory failure can effectively improve the patient′s respiratory function and lung function indicators, and the prognosis is better.At the same time, it significantly reduces the serum procalcitonin level, and during the treatment period No adverse reactions have been added, and safety is guaranteed.

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