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外泌体在破骨细胞分化中的研究进展

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Author:: No author available

Journal Title:: China Clinical Practical Medicine

Issue:: 3

DOI:: 10.3760/cma.j.cn115570-20210331.00942

Key Word:: 外泌体;破骨细胞;骨质疏松;骨重建;肿瘤;间充质细胞

Abstract：正常的骨代谢取决于成骨细胞骨形成作用和破骨细胞骨吸收作用之间的动态平衡，一旦骨稳态被破坏，会导致一些骨相关疾病的发生。外泌体作为细胞间通讯的一种媒介，包装和运载蛋白质、脂质、mRNA和miRNA等生物活性物质，作用于靶细胞并调控其代谢。破骨细胞是机体唯一可以进行骨吸收的细胞。近年来的研究发现，一些细胞分泌的外泌体对破骨细胞的分化起到重要的作用，进而影响着骨重建机制，利用其可调节及可修饰的特点，外泌体甚至可以作为临床上骨相关疾病治疗的新靶点。

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