Abstract： Objective:To investigate the effect of dexmedetomidine in the operation anesthesia of senile hypertensive intracerebral hemorrhage.Methods:A total of 60 hypertensive cerebral hemorrhage patients(31 males and 29 females, aged(68.42±4.86)years old, ranging in age from 60 to 80 years old)were admitted to the department of Neurosurgery of Shenzhen Bao ′an Central Hospital from October 2018 to April 2020 and planned to receive emergency surgical treatment were selected.The patients were randomly divided into dexmedetomidine group and normal saline group by random number table method, 30 cases in each group.Dexmedetomidine group was prepared into 4 μg/mL solution, and 0.5 μg/kg was given 10 min before general anesthesia induction, infusion 10 min, and 0.3 μg/kg was pumped until respiratory recovery(T 5)during the operation.The normal saline group received intravenous injection of the same volume of normal saline in the same period.Hemodynamic indexes, including systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate and pulse oxygen saturation, were recorded at admission(T 0), induction(T 1), endotracheal intubation(T 2), operation beginning(T 3), operation end(T 4), and T 5 in the two groups.The operative time, intraoperative blood loss, and the dosage of vasoactive drugs(urapidil, norepinephrine, esmolol, atropine)and anesthetic drugs(propofol)in the two groups were also studied. Results:There were statistically significant differences in systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate between the two groups at T 1, T 2, T 3, T 4 and T 5( P<0.05). The amount of intraoperative blood loss in the dexmedetomidine group[(456.67±58.33)ml]was less than that in the normal saline group[(505.00±71.14)ml], and the difference was statistically significant( P<0.05). The dosage of propofol[(867.33±52.06)mg], urapidil[(26.67±6.06)mg], esmolol[(11.67±7.47)mg]in the normal saline group were more than those in the dexmedetomidine group, the dosage of atropine[(0.08±0.19)mg]in the normal saline group was less than that in the dexmedetomidine group, the differences were statistically significant( P<0.05). Conclusion:Dexmedetomidine can make hemodynamic indexes more stable, reduce the usage of propofol, urapidil and esmolol, increase the usage of atropine, and reduce the amount of blood loss during surgery.