Abstract: Objective:To investigate the prognostic value of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)ratio(AST/ALT)in colorectal cancer patients with liver metastasis.Methods:A retrospective study was performed on 118 cases of patients with colorectal cancer complicated with liver metastasis who were admitted from January 2014 to January 2018, 76 cases of male, 42 cases of female, aged(60.71±10.42)years old, ranging from 27 to 75 years old.Patients were divided into the high-AST/ALT group and the low-AST/ALT group according to the ratio of AST and ALT median(1.15), the serum indicators of preoperative liver function.The basic data and clinical data of patients were collected, including gender, age, preoperative AST and ALT levels within a week, carcinoembryonic antigen(CEA)levels of tumor markers, vascular tumors of primary lung cancer whether merger oven plug, primary lung cancer are focal differentiation degree, whether primary lung cancer are focal lymph node metastasis, primary lung cancer, liver metastatic carcinoma infiltration depth oven focal hepatic metastases tumor diameter, number, liver metastases of cancer distribution characteristics, and the comparison.Univariate and multivariate analyses were performed to determine whether AST/ALT was a prognostic factor.Results:There were statistically significant differences in preoperative carcino-embroyonic antigen, AST and ALT levels, depth of primary cancer invasion, diameter, number and distribution of liver metastases between the high-AST/ALT and low-AST/ALT groups( P<0.05); the overall survival of the low-AST/ALT group was better than that of the high-AST/ALT group( χ2=12.995, P<0.001); high AST/ALT was an independent risk factor for low survival. Conclusion:The prognosis of patients with liver metastasis from colorectal cancer with high preoperative AST/ALT ratio was poor.AST/ALT ratio could be used as one of the clinical prognostic indicators.