Abstract： Objective:To investigate the effect of dexmedetomidine combined with parecoxib sodium on pain and inflammatory factors in elderly patients with hip fracture after advanced analgesia.Methods:A retrospective study was performed on 89 cases of elderly patients with hip fracture who were admitted from April 2018 to March 2019.There were 40 males and 49 females, aged(75.35±4.87)years old, ranged from 65 to 85 years old.Patients were randomly divided into the combined analgesia group( n=45)and conventional anesthesia group( n=44). Dexmedetomidine combined with parecoxib sodium was injected into the combined analgesia group before anesthesia, and normal saline of the same volume was injected into the conventional anesthesia group before anesthesia.The levels of Visual Analog Scale(VAS), interleukin-1β(IL-1β)and interleukin-6(IL-6)of the two groups and the incidence of adverse reactions were compared. Results:VAS in the combined analgesia group after[(1.53±0.55)points], 4 hours after surgery[(2.27±0.66)points], 6 hours after surgery[(2.09±0.64)points], and 24 h after surgery[(1.56±0.65)points]were lower than those in the conventional anesthesia group[(1.77±0.57)points, (2.59±0.69)points, (3.11±1.01)points, (2.58±0.81)points], and the difference was statistically significant( P<0.05). There was no significant difference in IL-1β and IL-6 levels between the combined analgesia group and the conventional anesthesia group( P>0.05). The level of IL-1 in the combined analgesia group was lower than that in the conventional anesthesia group[(16.40±3.78)pg/ml, (20.14±4.85)pg/ml, (15.57±3.26)pg/ml]at 4 h[(11.54±2.37)pg/ml], 6 h[(14.58±3.11)pg/ml]and 24 h[(10.36±2.13)pg/ml]. The level of IL-6 in the combined analgesia group was lower than that in the conventional anesthesia group[(63.20±7.74)pg/ml, (81.54±8.16)pg/ml, (50.36±6.54)pg/ml)at 4 h[(46.17±6.24)pg/ml], 6 h[(60.82±7.21)pg/ml], and 24 h[(36.29±4.78)pg/ml], with statistically significant differences( P<0.05). There was no significant difference in the incidence of adverse reactions between the combined analgesia group and the conventional anesthesia group( P>0.05). IL-1β levels of the combined analgesia group at 4 hours after surgery[(11.54±2.37)pg/ml], 6 hours after surgery[(14.58±3.11)pg/ml], and 24 hours after surgery[(10.36±2.13)pg/ml]were lower than those of the conventional anesthesia group[(16.40±3.78)pg/ml, (20.14±4.85)pg/ml, (15.57±3.26)pg/ml]. IL-6 levels of the combined analgesia group at 4 hours after surgery[(46.17±6.24)pg/ml], 6 hours after surgery[(60.82±7.21)pg/ml], 24 hours after surgery[(36.29±4.78)pg/ml]were lower than those of the conventional group[(63.20±7.74)pg/ml, (81.54±8.16)pg/ml, (50.36±6.54)pg/ml], and the differences were statistically significant( P<0.05). There was no significant difference in the incidence of adverse reactions between the combined analgesia group and the conventional anesthesia group( P>0.05). Conclusion:Dexmedetomidine combined with parecoxib sodium can improve the anesthetic effect of elderly patients with hip fracture surgery, relieve postoperative pain, inhibit the body inflammation, and is safe and reliable.