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蛋白因子Vasohibin-1在肿瘤中的研究进展

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Author:: No author available

Journal Title:: China Clinical Practical Medicine

Issue:: 2

DOI:: 10.3760/cma.j.issn.1673-8799.2019.02.019

Key Word:: Vasohibin-1;内皮细胞;血管生成;肿瘤;蛋白因子

Abstract： Vasohibin-1(VASH1)作为一个新近发现的血管生成抑制蛋白备受关注,是目前唯一的负反馈调节血管生成的蛋白因子. VASH1不仅调控血管形成,还能够参与多种病理改变,如影响肿瘤的进展与预后,VASH1的下调可促进肿瘤的发生和转移.本文主要对VASH1的具体特点、生物活性及其对肿瘤病变的调控与影响的研究进展进行综述,为临床病变的诊断和药物治疗提供新思路.

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