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墨蝶呤还原酶和四氢生物蝶呤与神经病理性疼痛的研究进展

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Author:: No author available

Journal Title:: China Clinical Practical Medicine

Issue:: 6

DOI:: 10.3760/cma.j.issn.1673-8799.2018.06.021

Key Word:: 墨蝶呤还原酶;神经病理性疼痛;四氢生物蝶呤

Abstract：神经病理性疼痛是由神经系统原发性损害和功能障碍所引起的疼痛,其属于一种慢性疼痛,疼痛表现为自发性疼痛、痛觉过敏、异常疼痛和感觉异常等临床特征.由于发病机制尚不明确,其治疗效果不尽如意.四氢生物蝶呤(BH4)已被证实是各种激素、炎症因子和神经递质合成所必需的辅因子.墨蝶呤还原酶(SPR)是BH4合成过程的一个必不可少的限速酶.炎症因子可能通过某个(些)信号转导通路导致神经病理性疼痛的发生.而炎症因子的产生与机体内的BH4存在内在的必然联系,机体内SPR的含量和活性的变化均会影响BH4的合成,所以SPR在神经病理性疼痛产生中扮演了重要角色.本文就当前SPR与神经病理性疼痛关系的研究进展作一综述.

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