Abstract： Objective To investigate the application value of Xuebijing in treatment of lung injury after traumatic brain injury. Methods A total of 90 rats with traumatic brain injury models were estab-lished and randomly divided into the physiological saline group,TBI model group and Xuebijing intervention group,with 30 cases in each group. The inflammatory factor C-reactive protein was statistically significantly analyzed. Results After 24 hours of treatment,the inflammatory factor C-reactive protein in the physiologi-cal saline group,TBI model group and Xuebijing intervention group were(64. 42 ± 13. 22)mg/L,(63. 85 ± 14. 36)mg/L and(63. 83 ± 13. 51) mg/L,and there was no statistically significant difference between the three groups( P >0. 05 ) . The inflammatory factor C-reactive protein in the Xuebijing intervention group were(31.52 ±10.02)mg/L at Day 7,(21.35 ±9.54)mg/L at Day 14 and(13.14 ±3.06)mg/L at Day 21,which were significantly better than those in the physiological saline group and TBI model group( P<0. 05). Conclusion Xuebijing in treatment of lung injury after trauma brain injury can significantly im-prove the level of inflammatory factor C-reactive protein,which is worth to be clinical promoted.