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COPD患者外周血中C反应蛋白、肿瘤坏死因子α、白细胞介素-6长期重复性与相关性分析
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- Author:
- No author available
- Journal Title:
- China Clinical Practical Medicine
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1673-8799.2017.04.012
- Key Word:
- 慢性阻塞性肺疾病;C-反应蛋白;肿瘤坏死因子-α;白细胞介素-6
Abstract： 目的 探讨慢性阻塞性肺疾病(COPD)稳定期患者外周血中C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)与白细胞介素-6(IL-6)12个月内的长期重复性及三者之间的相关性,以此探究COPD的发病机制.方法 选取山西医科大学附属汾阳医院呼吸内科就诊的47例COPD患者,对其随访12个月,测定患者第1、6、12个月的外周血中CRP、TNF-α、IL-6水平.采用最小显著性差异(LSD)法与单因素方差分析(one-way ANOVA)法观察重复性,及采用Pearson相关分析法确定访问的系统性标志物之间的关系.结果 3个标志物都各自具有长期重复性,差异无统计学意义(P>0.05);CRP与IL-6显著相关,差异有统计学意义(r=0.760,P=0.000;r=0.644,P=0.000;r=0.365,P=0.012).结论 COPD稳定期患者外周血中CRP,TNF-α与IL-6炎症标志物存在长期重复性,CRP与IL-6之间存在相关性.
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