Paper - WANFANG MED ONLINE

You Position: Home > Paper

成人长骨大范围骨缺损治疗的研究进展

( views:34, downloads:81 )

Author:: No author available

Journal Title:: 中国临床实用医学

Issue:: 6

DOI:: 10.3760/cma.j.issn.1673-8799.2016.06.036

Key Word:: No keyword available

Abstract：目前，临床上成人长骨大范围骨缺损的治疗仍然面临众多难题，且因各种原因引起的大范围骨缺损呈上升趋势，临床骨科工作者需高度重视。造成大范围骨缺损的原因有很多，主要包括开放伤后、慢性骨髓炎、肿瘤剔除后及骨发育畸形等[1]。临床上，限制在5 cm以下骨缺损治疗方法较多，治疗难度小，如自体骨移植技术[2]，但对超过5 cm的大范围骨缺损者，由于愈合困难，治疗方式选择上较为棘手，给患者带来生理和精神双重负担，因此选取合适的治疗方法对患者的术中操作及术后康复尤为关键。近年来成人大范围骨缺损临床治疗有了新的突破，并取得了良好疗效，Ilizarov骨搬运技术、Masquelel诱导膜技术及组织工程技术等应用于临床。该研究对成人大范围骨缺损的主要治疗现状作一综述。

Reference

[1]解冰,田竞,荆延峰,等.膜诱导技术治疗成人长骨慢性骨髓炎早期临床疗效[J].2015,(1).
[2]王耀一,杨新明,胡振顺,等.利用显微外科技术促进组织工程骨血管化的研究进展[J].2011,(11).
[3]孟宪勇,杨新明,彭阿钦.骨组织工程在修复骨缺损中的研究现状[J].2011,(2).
[4]李远辉,杨运发,胡汉生,等.带血管腓骨移植修复四肢大段骨缺损：可有效促进骨愈合[J].2015,(11).
[5]李靖,王臻,郭征,等.带血管腓骨复合异体骨修复长骨肿瘤切除后骨缺损[J].2011,(6).
[6]徐建强,胡蕴玉,张超,等.大段仿生活性人工骨修复兔长骨缺损的实验研究[J].2005,(9).
[7]裴国献.组织工程学--21世纪面临的机遇与挑战[J].2006,(1).
[8]刘亚平,程国良,潘达德,等.带血管腓骨移植的远期疗效报告[J].2001,(1).
[9]J F, Keating,A H R W, Simpson,C M, Robinson.The management of fractures with bone loss.[J].2005,87(2).
[10]Qureshi, Ammar T.,Doyle, Andrew,Chen, Cong,etc.Photoactivated miR-148b-nanoparticle conjugates improve closure of critical size mouse calvarial defects[J].2015,12.
[11]N K, Kanakaris,N, Lasanianos,G M, Calori,etc.Application of bone morphogenetic proteins to femoral non-unions: a 4-year multicentre experience.[J].2009,40 Suppl 3.
[12]G I, Taylor,G D, Miller,F J, Ham.The free vascularized bone graft. A clinical extension of microvascular techniques.[J].1975,55(5).
[13]Mir MR,Hussain A,Dhar SA,etc.Management of lower limb fractures in polytrauma patients with delayed referral in a mass disaster The role of the Ilizarov method in conversion osteosynthesis.[J].2008,39(8).
[14]Yinze, Diao,Qingjun, Ma,Fuzhai, Cui,etc.Human umbilical cord mesenchymal stem cells: osteogenesis in vivo as seed cells for bone tissue engineering.[J].2009,91(1).
[15]Nikolaos G Lasanianos,Peter V Giannoudis,Nikolaos K Kanakaris.Current management of long bone large segmental defects[J].2010,24(2).
[16]Lascombes P,Peretti G,Deromedis B,etc.Gradual femoral lengthening with the Albizzia intramedullary nail.[J].2003,85/A(5).
[17]F, Accadbled,P, Mazeau,F, Chotel,etc.Induced-membrane femur reconstruction after resection of bone malignancies: three cases of massive graft resorption in children.[J].2013,99(4).
[18]G A, Ilizarov.The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation.[J].1989,(238).
[19]M R, Urist,K, Sato,A G, Brownell,etc.Human bone morphogenetic protein (hBMP).[J].1983,173(2).
[20]Gannon FH,Milne E,Lindsey RW,etc.The efficacy of cylindrical titanium mesh cage for the reconstruction of a critical-size canine segmental femoral diaphyseal defect.[J].2006,24(7).
[21]de Billy B,Sales de Gauzy J,Accadbled F,etc.Intercalary segmental reconstruction of long bones after malignant bone tumor resection using primary methyl methacrylate cement spacer interposition and secondary bone grafting: the induced membrane technique.[J].2011,31(5).
[22]Long Li,Guangliang Zhou,Yi Wang,etc.Controlled dual delivery of BMP-2 and dexamethasone by nanoparticle-embedded electrospun nanofibers for the efficient repair of critical-sized rat calvarial defect[J].2015,37.
[23]F C, Wei,T A, El-Gammal,C H, Lin,etc.Free fibula osteoseptocutaneous graft for reconstruction of segmental femoral shaft defects.[J].1997,43(5).
[24]Brandoff JF,Silber JS,Vaccaro AR.Contemporary alternatives to synthetic bone grafts for spine surgery.[J].2008,37(8).
[25]Saifzadeh S,Redl H,Schutz MA,etc.The challenge of establishing preclinical models for segmental bone defect research.[J].2009,30(12).
[26]Giannoudis PV,Faour O,Goff T,etc.Masquelet technique for the treatment of bone defects: tips-tricks and future directions.[J].2011,42(6).
[27]胡金龙.组织工程学技术治疗骨缺损的最新研究进展[J].2013,(2).
[28]陈振光.国内带血管蒂骨、骨膜瓣移位术近况[J].2013,(1).
[29]Burkhart KJ,Rommens PM.Intramedullary application of bone morphogenetic protein in the management of a major bone defect after an Ilizarov procedure.[J].2008,90(6).
[30]Lieberman JR,Baltzer AW.Regional gene therapy to enhance bone repair.[J].2004,11(4).
[31]Tagliabue L,Albisetti W,d'Imporzano M,etc.Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions: a prospective randomised clinical study on 120 patients.[J].2008,39(12).
[32]A C, Masquelet,F, Fitoussi,T, Begue,etc.[Reconstruction of the long bones by the induced membrane and spongy autograft].[J].2000,45(3).