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Effects of autologous bone marrow stem cell transplantation on coagulation,liver function and prognosis of patients with liver cirrhosis

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Journal Title:
China Clinical Practical Medicine
Key Word:
肝硬化;自体骨髓干细胞;移植;凝血;肝功能;Liver cirrhosis;Autologous bone marrow stem cell;Transplantation;Coagulation;Liver function

Abstract´╝Ü ObjectiveTo study the effects of autologous bone marrow stem cell transplantation on coagulation, liver function and prognosis of patients with liver cirrhosis.Methods From October 2013 to July 2015,54 patients with liver cirrhosis treated were studied in the Pingdingshan First People's Hospital. After admission, all patients underwent bone marrow puncture and about 150 to 200 ml bone marrow was collected. After conventional anticoagulation and separation, about 20 ml cell suspension was made. Digital subtraction angiography (DSA) and femoral artery puncture were performed to examine the hepatic artery. The stem cell suspension was injected slowly into the liver via the hepatic artery. After injection, all patients were observed for 10 weeks during hospitalization and follow-up, and periodic review was performed. The follow-up outcome was recorded. The coagulation function indexes [prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB)] and liver function indexes [serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), serum albumin (ALB)] were compared before and after transplantation.Results Autologous bone marrow stem cell transplantation was successful in 54 patients. Ascites and digestive tract symptoms were relieved effectively. There only were nausea and vomiting, low fever and other mild adverse symptoms, and the incidence of adverse symptoms was 14.81%; 10 weeks after transplantation, coagulation function indexes [PT (16.03±3.85) s, TT (23.35±2.65) s, APTT (38.24±3.14) s] were lower than those before transplantation while FIB [(2.38±0.75) g / L] was higher than that before transplantation [(2.02±0.88) g/L] (P<0.05); 10 weeks after transplantation, liver function indexes [ALT (81.37±19.42) U/L, AST (59.82±18.64) U/L, TBIL (34.21±15.52) μmol/L] were lowerthan those before transplantation [(92.42±22.15) U/L, (72.51±32.27) U/L, (43.76±24.35) μmol/L] (P<0.05). ALB was higher than that before transplantation but there were no significant differences between the two (P>0.05).Conclusions Autologous bone marrow stem cell transplantation is with advantages of high success rate of operation and high safety, etc.It can better regulate and improve coagulation function and liver function in patients with liver cirrhosis. It is of important significance in promoting outcome and improving the quality of life.

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