Abstract： Objective To explore Correlation of Transient receptor potential melastatin 4 (TRPM4) to human aging changes of articular cartilage and to cartilage damage. Methods Collect knee amputation trauma patients, divided according to age group 20 to 29 years, 30 to 39 age group, 40 to 49 age group, each six cases; collect OA articular cartilage knee replacement patients,six cases of mild cartilage damage group, six cases of severe cartilage damage. The degeneration of cartilage was evaluated by revised Safranin O. The TRPM4 mRNA was assessed by RT-PCR and the TRPM4 protein expression examined by western blot. Immunohistochemistry and immunofluorescence investigate the localization of TRPM4 within human articular cartilage and the cellular distribution. Results Safranin O show that with increasing age, the degeneration of articular cartilage gradually , OA patients are more obvious damaged. TRPM4 was expressed in human cartilage.With the growth of age and worsening cartilage damage,TRPM4 mRNA and protein expressions increased obviously in cartilage(P<0.05).In normal cartilage, human age and TRPM4 protein expression was positively correlated (r=0.632,P<0.01). The damage degree of cartilage was positively correlated with TRPM4 expression(r=0.714,P<0.01).TRPM4 mainly located in the cell membrane of superficial cartilage chondrocyte. Conclusion TRPM4 expression is correlated with the human age and the damage degree of knee joint OA.