Abstract： Objective Analysis of entecavir combined with autologous bone marrow stem cell transplantation on the treatment of patients with liver cirrhosis.Methods Select decompensated liver cirrhosis 78 patients.From the patient's bone marrow posterior superior iliac spine,Purification of in vitro bone marrow-derived stem cells,Through the femoral artery puncture implanted liver.After surgery in patients 2,4,8 weeks to check the relevant laboratory parameters.Results Our first four weeks after surgery and eight weeks found that most patients with clinical signs and symptoms have markedly improved,Ascites reduce or mitigate the total 68 cases and 72 cases,fatigue symptoms improved with 69 cases and 75 cases,reduce bloating in patients with 69 cases and 72 cases.We found that in the first four weeks after surgery,a number of indicators have been significant changes,ALT,AST,TBIL decreased,ALB,PT％ improved significantly.Conclusion BMSC transplantation in liver itself is a significant advancement of clinical treatment and beneficial supplement BMSC liver transplantation to patients a new choice.