Abstract: Objective To explore the application of evidence-basednursing care and postoperative radiotherapy for breast cancer patients with skin reactions and effective means of intervention. Methods According to the specific conditions of 76 cases of cutaneous reactions in patients, propose nursing issue, collect relevant evidence,combined with the actual developmentand work outpractical nursing care plan, and take the appropriatenursing intervention. Results 76 patients with skin reactions after the intervention,were able to mitigate,to alleviate the suffering. The patient can completeradiation therapy successfully andachieve an effective expose dose. Conclusion Using evidence-based nursingcareto identify the factors of skin damage for breast cancer patients undergoing radiotherapy, explore scientific and integrity nursing programs, can improve the quality of care.