Abstract: Objective To study the therapy effect of β-Aescin and chlorphenamine on the treatment of patien ts with Shoulder-hand syndrome after stroke(SHS).Methods 84 patientswith SHS were divided randomized into treatment group and control group.Control group received Conventional treatments and rehabilitation training,traetment group accepted β-Aescin and chlorphenamine.Before and after treatment,the two groups were assessed by the Fugl-Meyer assessment(FMA),and clinical efficacy was compared in two groups.Results After treatment,efficient and the gain of scores in the treatment group were obviously higher than those in the control group(P<0.05).Conclusion β-Aescin and chlorphenamine is effective in the patients with SHS.