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Clinical effect of postoperative injection of Analgecine on patient-controlled intravenous analgesia of Fentanyl

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Abstract´╝Ü Objective To compare the effect of preoperative intravenous injection of Analgecine on the analgesic efficacy and complications of patient-controlled intravenous analgesia(PCA) of different doses of fenta- nyl in postoperative total hysterectomy patients. Methods 120 patients undergoing total hysterectomy in general anesthesia were randomly divided into four groups with thirty cases each. Fentanyl 1 mg in group A ,fentanyl 0.5 mg in group B,fentanyl 0. 7 mg in group C,fentanyl 0. 5 mg in group D. The drugs in each group were diluted to 100 ml and infused by pumps. Besides,the patients in group C and D were injected with Anaigecine 3.6 U and 7. 2 U at the night before the operation, preoperation and postoperation respectively. The visual analog scale (VAS) ,times of PCA and incidence of side effects were recorded during the period of postoperative 24 hours. Results The VAS of group B at 2 h after operation was significantly higher than that of group A, C and D (P < 0.05) ,which became similar 2 h later(P > 0. 05). The demanding times for supplemental bolus in group B was also significantly higher than that of A, C and D (P < 0. 05). The incidence of nausea, vomiting, itching, somno- lence in group B, C and D were significantly less than those in group A (P < 0.05). No respiratory depression or abnormal bleeding occurred in four groups. Conclusion Preoperative intravenous injection of Analgecine has a better effect on patient-controlled intravenous analgesia(PCIA) of fentanyl and can reduce fentanyl requirement and its side effects in total hysterectomy patients.

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