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外泌体源性miRNA在胰腺癌诊断中的研究现状

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 6

DOI:: 10.3760/cma.j.cn115667-20210816-00149

Key Word:: 胰腺癌;外泌体;外泌体源性miRNA;生物标记物

Abstract：外泌体是一种包含RNA、DNA片段及蛋白质等多种生物活性物质的纳米级微囊泡，由多泡体与胞膜融合后分泌到细胞外环境中。外泌体内的微小RNA(miRNA)主要参与干细胞的分化、血细胞的生成、器官的形成、肿瘤的发生发展及转移等。外泌体miRNA因其较高的稳定性和易于检测的优点，被认为是具有潜力的生物学检测指标。本文就外泌体miRNA在胰腺癌诊断中的研究现状进行综述。

Reference

[1]曾凯.外泌体源性miRNA在消化道肿瘤中的研究进展[J].2020,(1).
[2]陈石林,马敏,阎磊,等.miR-1231在胰腺癌患者血浆和胰腺癌细胞外泌体中的表达及临床意义[J].2019,(1).
[3]Xu, Zhang,Si, Shi,Bo, Zhang,etc.Circulating biomarkers for early diagnosis of pancreatic cancer: facts and hopes.[J].2018,8(3).
[4]Monticelli, Silvia,Emming, Stefan,Chirichella, Michele.MicroRNAs as modulators of T cell functions in cancer[J].2018,430.
[5]Xiaofan,Pu,Guoping,Ding,Mingjie,Wu,etc.Elevated expression of exosomal microRNA-21 as a potential biomarker for the early diagnosis of pancreatic cancer using a tethered cationic lipoplex nanoparticle biochip.[J].2020,19(3).
[6]Risheng, Que,Guoping, Ding,Jionghuang, Chen,etc.Analysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinoma.[J].2013,11(1).
[7]Zhou, Xin,Lu, Zipeng,Wang, Tongshan,etc.Plasma miRNAs in diagnosis and prognosis of pancreatic cancer: A miRNA expression analysis[J].2018,673.
[8]Congcong,Zhang,Pei,Miao,Mingyuan,Sun,etc.Progress in miRNA Detection Using Graphene Material-Based Biosensors.[J].2019,15(38).
[9]Tang, Yue-Ting,Huang, Yi-Yao,Zheng, Lei,etc.Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum[J].2017,40(3).
[10]Madhavan, Bindhu,Yue, Shijing,Galli, Uwe,etc.Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity[J].2015,136(11).
[11]Laura M. Doyle,"ORCID":"http:\/\/orcid.org\/0000-0003-2494-4172Michael Zhuo Wang.Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis[J].2019,8(7).
[12]Nils Ludwig.Isolation and Analysis of Tumor-Derived Exosomes[J].2019,127.
[13]Dobhal Garima,Datta Amrita,Ayupova Deanna,etc.Isolation, characterisation and detection of breath-derived extracellular vesicles[J].2020,10(1).
[14]Yi-Fan, Xu,Bethany N, Hannafon,Yan D, Zhao,etc.Plasma exosome miR-196a and miR-1246 are potential indicators of localized pancreatic cancer.[J].2017,8(44).
[15]李明浙,杨尹默.外泌体在胰腺癌中的研究现状与展望[J].2020,(1).
[16]Rahbari, Mohammad,Rahbari, Nuh,Reissfelder, Christoph,etc.Exosomes: novel implications in diagnosis and treatment of gastrointestinal cancer[J].2016,401(8).
[17]Sangiliyandi,Gurunathan,Min-Hee,Kang,Muniyandi,Jeyaraj,etc.Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes.[J].2019,8(4).
[18]Bray Freddie,Ferlay Jacques,Soerjomataram Isabelle,etc.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].2018,68(6).
[19]Moritz,Reese,Isabelle,Flammang,Zixuan,Yang,etc.Potential of Exosomal microRNA-200b as Liquid Biopsy Marker in Pancreatic Ductal Adenocarcinoma.[J].2020,12(1).
[20]Lucia Mincheva-Nilsson,Vladimir Baranov,Olga Nagaeva,etc.Isolation and Characterization of Exosomes from Cultures of Tissue Explants and Cell Lines[J].2016,(Suppl.115).
[21]Lai, Xianyin,Wang, Mu,McElyea, Samantha Deitz,etc.A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer[J].2017,393.
[22]Mayerle, Julia,Kalthoff, Holger,Reszka, Regina,etc.Metabolic biomarker signature to differentiate pancreatic ductal adenocarcinoma from chronic pancreatitis[J].2018,67(1).
[23]Yang, Ke,Li, Jining,de la Chapelle, Marc Lamy,etc.A terahertz metamaterial biosensor for sensitive detection of microRNAs based on gold-nanoparticles and strand displacement amplification[J].2021,175.
[24]Laurent Muller,Chang-Sook Hong,Donna B. Stolz.Isolation of biologically-active exosomes from human plasma[J].2014,411.
[25]Garcea, G.,Neal, C. P.,Pattenden, C. J.,etc.Molecular prognostic markers in pancreatic cancer: A systematic review[J].2005,41(15).
[26]Hannafon, Bethany N.,Ding, Wei-Qun.Intercellular Communication by Exosome-Derived microRNAs in Cancer.[J].2013,14(7).
[27]Kioomars Saliminejad,Hamid Reza Khorram Khorshid,Shahrzad Soleymani Fard,etc.An overview of microRNAs: Biology, functions, therapeutics, and analysis methods[J].2019,234(5).
[28]Zhu Le,Sun Hao-Ting,Wang Shun,etc.Isolation and characterization of exosomes for cancer research[J].2020,13(1).
[29]Shushan, Yan,Bing, Han,Shunyuan, Gao,etc.Exosome-encapsulated microRNAs as circulating biomarkers for colorectal cancer.[J].2017,(Spec ).
[30]Xu, Rong,Greening, David W.,Zhu, Hong-Jian,etc.Extracellular vesicle isolation and characterization: toward clinical application[J].2016,126(4).
[31]Takuma, Goto,Mikihiro, Fujiya,Hiroaki, Konishi,etc.An elevated expression of serum exosomal microRNA-191, -?21, -451a of pancreatic neoplasm is considered to be efficient diagnostic marker.[J].2018,18(1).
[32]Kosaka,Nobuyoshi.Decoding the Secret of Cancer by Means of Extracellular Vesicles[J].2016,5(2).
[33]Zhao, Junxiang,Liu, Chao,Li, Yike,etc.Thermophoretic Detection of Exosomal microRNAs by Nanoflares[J].2020,142(11).
[34]Joshi, Gayatri K.,Deitz-McElyea, Samantha,Liyanage, Thakshila,etc.Label-Free Nanoplasmonic-Based Short Noncoding RNA Sensing at Attomolar Concentrations Allows for Quantitative and Highly Specific Assay of MicroRNA-10b in Biological Fluids and Circulating Exosomes[J].2015,9(11).
[35]Takahasi Kunihiko,Iinuma Hisae,Wada Keita,etc.Usefulness of exosome-encapsulated microRNA-451a as a minimally invasive biomarker for prediction of recurrence and prognosis in pancreatic ductal adenocarcinoma[J].2018,25(2).
[36]Xiaojie, Yu,Margarete, Odenthal,Jochen W U, Fries.Exosomes as miRNA Carriers: Formation-Function-Future.[J].2016,(12).
[37]Ariston Gabriel Abakundana Nsenga,Wang Fang,Jiao Qinlian,etc.The involvement of exosomes in the diagnosis and treatment of pancreatic cancer[J].2020,19(1).