You Position: Home > Paper
CAMK1及SPHK1在胰腺癌组织中的表达及与临床病理特征和预后的关系
( views:0, downloads:0 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Pancreatology
- Issue:
- 5
- DOI:
- 10.3760/cma.j.cn115667-20210801-00143
- Key Word:
- 胰腺癌;钙/钙调素依赖性蛋白激酶1;鞘氨醇激酶1;预后
Abstract： 回顾性分析105例行手术切除且经病理确诊的胰腺癌患者的临床资料，探讨胰腺癌组织CAMK1、SPHK1的表达与临床病理特征及预后的关系。结果显示，胰腺癌组织CAMK1、SPHK1均呈高表达，其高表达组的临床分期，远处转移及脉管浸润与低表达组比较，差异均有统计学意义，且高表达与患者的总生存期短有关，是影响胰腺癌患者预后的生物学指标。
- [1]中国抗癌协会胰腺癌专业委员会.胰腺癌综合诊治指南（2018版）[J].2018,(7).
- [2]W,Shi,Y,Lu,R,Gong,etc.Serum miR-629 is a novel molecular marker for diagnosis and the prognosis of pancreatic cancer.[J].2018,22(16).
- [3]Seung Bin Park,Byung-il Choi,Beom Jae Lee,etc.Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation[J].2020,65(8).
- [4]Hart, Peter C.,Chiyoda, Tatsuyuki,Liu, Xiaojing,etc.SPHK1 Is a Novel Target of Metformin in Ovarian Cancer[J].2019,17(4).
- [5]Peng,Liu,Quan-Quan,Sun,Tong-Xin,Liu,etc.Serum lncRNA-UFC1 as a potential biomarker for diagnosis and prognosis of pancreatic cancer.[J].2019,12(11).
- [6]Hailin Tan,Guiming Zhang,Xuecheng Yang,etc.Peimine inhibits the growth and motility of prostate cancer cells and induces apoptosis by disruption of intracellular calcium homeostasis through Ca\n 2+\n\/CaMKII\/JNK pathway[J].2019,60(1).
- [7]Kizuki Yuza,Masato Nakajima,Masayuki Nagahashi,etc.Different Roles of Sphingosine Kinase 1 and 2 in Pancreatic Cancer Progression[J].2018,232.
- [8]Joshua S,Brzozowski,Kathryn A,Skelding.The Multi-Functional Calcium/Calmodulin Stimulated Protein Kinase (CaMK) Family: Emerging Targets for Anti-Cancer Therapeutic Intervention.[J].2019,12(1).
- [9]Ma, Yuefeng,Xing, Xin,Kong, Ranran,etc.SphK1 promotes development of non-small cell lung cancer through activation of STAT3[J].2021,47(1).
- [10]Bae, Go Eun,Do, Sung-Im,Kim, Kyungeun,etc.Increased Sphingosine Kinase 1 Expression Predicts Distant Metastasis and Poor Outcome in Patients With Colorectal Cancer[J].2019,39(2).
- [11]Zhengzhao,Li,Junyu,Lu,Guang,Zeng,etc.MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).[J].2019,10(11).