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肿瘤相关脂肪细胞在胰腺癌中的研究进展
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Pancreatology
- Issue:
- 3
- DOI:
- 10.3760/cma.j.cn115667-20200615-00093
- Key Word:
- 肿瘤相关脂肪细胞;胰腺癌;肿瘤微环境
Abstract： 胰腺癌肿瘤微环境中的脂肪细胞在癌细胞的作用下可以转变成一种特殊的促癌表型，称为肿瘤相关脂肪细胞(CAA)。CAA在胰腺癌中通过脂质代谢等途径参与了肿瘤细胞代谢重编程，缓解了氧和营养物质的供应不足，为癌细胞的生长和增殖提供了充足的能量。同时通过分泌脂肪因子、促炎因子和趋化因子以及与其他基质细胞相互作用，进一步促进了胰腺癌的侵袭和转移。
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