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急性坏死性胰腺炎大鼠腹腔巨噬细胞胱天蛋白酶募集域蛋白9、Toll样受体4的作用机制
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Pancreatology
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1674-1935.2019.03.012
- Key Word:
- 急性坏死性胰腺炎;胱天蛋白酶募集域蛋白9;siCARD9体外干扰;腹腔巨噬细胞;TOLL样受体4;p38丝裂原活化蛋白激酶;核转录因子κB
Abstract： 提取急性坏死性胰腺炎(ANP)大鼠腹腔巨噬细胞体外培养,通过携带靶向胱天蛋白酶募集域蛋白9(CARD9)的腺病毒感染巨噬细胞后,细胞TLR4、CARD9、NF-κB、p38MAPK基因表达均下降(P值均<0.05),多聚肌苷酸盐P4154干预可上调TLR4基因表达,进而上调CARD9、NF-κB、p38 MAPK基因的表达(P值均<0.05),提示ANP大鼠腹腔巨噬细胞存在TLR4/CARD9/NF-κB(p38MAPK)信号途径.
- [1]翁成钊,徐萍,杨志文,等.胱天蛋白酶募集域蛋白9在急性胰腺炎发病早期的作用机制[J].2015,(9).
- [2]翁成钊,徐萍,杨志文,等.急性胰腺炎早期胱天蛋白酶募集域蛋白9的动态变化及其临床意义[J].2015,(1).
- [3]朱彤,涂文娟,谈志丽,等.腺病毒对原代枯否细胞转染效率及增殖活性的影响[J].2016,(6).
- [4].Acute lung injury and ARDS in acute pancreatitis: Mechanisms and potential intervention[J].2010,(17).
- [5]Cole, Garry T.,Hung, Chiung-Yu,Castro-Lopez, Natalia.Card9-and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection[J].2016,84(4).
- [6]Gabrielli, Elena,Pericolini, Eva,Cenci, Elio,etc.Antibody Constant Region Peptides Can Display Immunomodulatory Activity through Activation of the Dectin-1 Signalling Pathway.[J].2012,7(8).
- [7]Mohlopheni Jackson, Marakalala,Lisa M, Graham,Gordon D, Brown.The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.[J].2010,2010.
- [8]Zhi-wen Yang,Xiao-xiao Meng.CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9-dependent NF-κB and P38MAPKs pathway[J].2017,21(6).
- [9]Jia L,Ren J,Cheng J,etc.Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion.[J].2011,24(6).
- [10]Srinivasula SM,Poyet JL,Guo Y,etc.CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.[J].2000,275(52).
- [11]Xu, Ping,Weng, Cheng-zhao,Yang, Zhi-wen,etc.The role of Card9 overexpression in peripheral blood mononuclear cells from patients with aseptic acute pancreatitis[J].2016,20(3).
- [12]Roth,S.,Ruland,J..Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation[J].2013,34(6).
- [13]陈诚,徐萍,王静,等.PI3K抑制剂对急性胰腺炎细胞因子和组织病理学评分的影响[J].2012,(36).
- [14]Hu, Wei,Jain, Aakanksha,Gao, Yajing,etc.Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation[J].2015,112(45).
- [15]Song, Zengfu,Zhou, Haoxin,Wang, Yongwei,etc.MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis[J].2016,283(4).
- [16]Colonna M.All roads lead to CARD9[J].2007,8(6).
- [17]范家乔,陈海龙.腹腔巨噬细胞在大鼠重症急性胰腺炎发病机制中作用[J].2014,(5).