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中药甘遂治疗重症急性胰腺炎的作用与机制研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 6

DOI:: 10.3760/cma.j.issn.1674-1935.2017.06.020

Key Word:: No keyword available

Abstract：重症急性胰腺炎(SAP)病理机制复杂,胰酶激活使机体释放大量的炎症因子,形成“瀑布”效应;作为应激反应中心器官的肠道,早期即有肠黏膜破坏、细菌与内毒素易位,后者刺激已活化的免疫细胞,释放过量细胞因子和炎症递质,诱导全身炎症反应综合征(systemic inflammatory response syndrome,SIRS),导致并加重多系统脏器功能衰竭(multiple organ failure,MOF)[1].实施外科手术并不能降低SAP的病死率[2].基于现代医学的非手术疗法,辅以中药“通腑泄热逐水”,因能显著改善SAP预后而被普遍重视[3-4].甘遂,作为峻下逐水的代表药之一,其治疗SAP的临床疗效明确且优于大黄.运用甘遂辅助治疗SAP已成为近年来研究的热点.

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