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miRNA-155与胰腺疾病

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 5

DOI:: 10.3760/cma.j.issn.1674-1935.2017.05.018

Key Word:: No keyword available

Abstract： microRNA(miRNA)是一类单链非编码RNA,是与多种疾病发生发展有关的新的调节分子家族之一.miRNA不编码蛋白,具有高度的保守性、时序性和组织特异性,通过与靶mRNA的3'端非编码区3'-UTR结合,降解或者抑制mRNA的翻译,导致靶基因的转录后沉默,从而参与靶基因功能的调节[1-3].miR-155位于人类21号染色体的非编码转录体BIC第3个外显子内,是一个多功能miRNA,它在多种炎症、自身免疫性疾病、肿瘤(结直肠癌、肝癌、胰腺癌、胃癌)等人体多种病理生理过程中发挥重要作用.miR-155在活化的各种免疫细胞中表达普遍升高,是免疫系统最主要的miRNA之一,参与天然免疫应答和特异性免疫应答.本文就miR-155在胰腺相关疾病中的作用做一综述.

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