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不可逆电穿孔技术在治疗胰腺癌中的应用

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 3

DOI:: 10.3760/cma.j.issn.1674-1935.2017.03.017

Key Word:: No keyword available

Abstract：胰腺癌是最致命的癌症之一,也是消化系统中常见的恶性肿瘤,预后较差,患者1年与5年生存率仅6%~27%[1].尽管手术切除是提高生存率的最佳途径,但大多数患者确诊时已属晚期而无法采取手术切除治疗.约20%的患者可进行手术切除,但他们的5年生存率低于20%[2].目前临床上有多种局部消融方法用于治疗胰腺癌.化学消融、冷冻消融等物理消融技术虽然在前、中期疗效显著,但由于消融时缺乏选择性,对消融区域及邻近区域血管、神经、胆管等其他正常组织破坏较大,并未显著延长患者总体生存期[3-4].随着电生理技术的发展,不可逆电穿孔(Irreversible electroporation,IRE)作为新的物理消融技术已逐渐应用于临床.有报道显示IRE的应用有利于提高患者的总体生存率,表现出广泛的应用前景,为胰腺癌的临床治疗提供新的思路.本文就IRE在胰腺癌治疗中的应用做一综述.

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