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生长抑素及其类似物在急性胰腺炎治疗中的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 2

DOI:: 10.3760/cma.j.issn.1674-1935.2017.02.018

Key Word:: No keyword available

Abstract：急性胰腺炎(AP)是常见的消化道疾病,发病率逐年升高,轻者可为自限性,重者可导致炎症反应综合征、多器官功能衰竭等严重并发症而危及生命.根据2013年美国AP指南[1],将有局部并发症和(或)有一过性(<48 h)器官衰竭的患者定义为中度AP(MSAP),将有持续(>48 h)器官衰竭的患者定义为重度AP(SAP).在治疗上,对胆源性胰腺炎可行内镜下乳头括约肌切开、鼻胆管引流等治疗,效果良好[2-3];对于饮酒、高脂血症等引起的AP,尤其是SAP,目前主要为支持和对症治疗,如液体复苏、早期营养支持等[3],合并感染性坏死时需要清创引流及应用抗生素等[4].生长抑素(somatostatin, SS)及其类似物被广泛应用于AP的治疗,但对其临床疗效、作用机制、应用剂量及应用时间等方面仍存在争议,本文就此做一综述.

Reference

[1]Z, Rakonczay,P, Hegyi,T, Takács,etc.The role of NF-kappaB activation in the pathogenesis of acute pancreatitis.[J].2008,57(2).
[2]I A, Kolotushkin,S I, Balnykov,L B, Shubin.[Estimation of the role of octreotide in treatment of severe pancreatic necrosis].[J].2015,(6).
[3]Mariola Śliwińska-Mossoń,Marta Veselý,Halina Milnerowicz.The clinical significance of somatostatin in pancreatic diseases[J].2014,75(4).
[4]Wang R,Tang C,Li J.Somatostatin and octreotide on the treatment of acute pancreatitis - basic and clinical studies for three decades.[J].2011,17(16).
[5]Haim Paran,Ami Mayo,Daphna Paran,etc.Octreotide Treatment in Patients with Severe Acute Pancreatitis[J].2000,45(11).
[6]Eva Murphy,Eric E. Prommer,Mary Mihalyo,etc.Octreotide[J].2010,40(1).
[7]Y F, Wang,M, Wu,B J, Ma,etc.Role of high mobility group box-1 and protection of growth hormone and somatostatin in severe acute pancreatitis.[J].2014,47(12).
[8]WUhl,M WB&#x000FC,chler,etc.A randomised, double blind, multicentre trial of octreotide in moderate to severe acute pancreatitis[J].1999,45(1).
[9]A, Andriulli,G, Leandro,R, Clemente,etc.Meta-analysis of somatostatin, octreotide and gabexate mesilate in the therapy of acute pancreatitis.[J].1998,12(3).
[10]Wei-Chih, Sun,Hoi-Hung, Chan,Kwok-Hung, Lai,etc.The efficacy of endoscopic papillary balloon dilation for patients with acute biliary pancreatitis.[J].2015,2015.
[11]Sah,R.P.,Dawra,R.K.,Saluja,A.K..New insights into the pathogenesis of pancreatitis[J].2013,29(5).
[12]Wan MH,Chen GY,Ren P,etc.Effect of somatostatin on immune inflammatory response in patients with severe acute pancreatitis.[J].2007,8(2).
[13]Enver Zerem.Treatment of severe acute pancreatitis and its complications[J].2014,(38).
[14]Usadel KH,Wullstein C,Bechstein WO,etc.Octreotide attenuates impaired microcirculation in postischemic pancreatitis when administered before induction of ischemia.[J].2008,86(7).
[15]Tenner,S.,Baillie,J.,Dewitt,J.,etc.American college of gastroenterology guideline: Management of acute pancreatitis[J].2013,108(9).
[16]M Ertugrul, Kafali,Mehmet, Gul,Husnu, Alptekin,etc.Is there a relationship between beginning time and efficiency of octreotide in the treatment of experimental acute pancreatitis?[J].2012,82(5).
[17]Lone Harild Ottesen,Allan Flyvbjerg,Preben Jakobsen,etc.The pharmacokinetics of octreotide in cirrhosis and in healthy man[J].1997,26(5).
[18]Yan, Bi,Tegpal, Atwal,Santhi Swaroop, Vege.Drug Therapy for Acute Pancreatitis.[J].2015,13(3).
[19]Giamarellos-Bourboulis EJ,Arvanitakis C,Arnaoutis TP,etc.The significance of the dosage adjustment of octreotide in the treatment of acute pancreatitis of moderate severity.[J].2001,48(42).
[20]B, Limberg,B, Kommerell.Treatment of acute pancreatitis with somatostatin.[J].1980,303(5).
[21]Jeffrey J. Easler,Stuart Sherman.Endoscopic Retrograde Cholangiopancreatography for the Management of Common Bile Duct Stones and Gallstone Pancreatitis[J].2015,25(4).
[22]Huang,Z.,Hu,B.,Wang,R.,etc.High-dose versus low-dose octreotide in the treatment of acute pancreatitis: A randomized controlled trial[J].2013,40.
[23]Tang C,Hu B,Liu L,etc.Role of neurocrine somatostatin on sphincter of Oddi contractility and intestinal ischemia reperfusion-induced acute pancreatitis in macaques.[J].2010,22(8).
[24]Swetha Kambhampati,Walter Park,Aida Habtezion.Pharmacologic therapy for acute pancreatitis[J].2014,(45).
[25]Dong,L.,Zhang,L.,Wang,L.,etc.The protection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression[J].2012,1475.