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重症急性胰腺炎血液高凝状态的诊断和治疗

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Author:: No author available

Journal Title:: Chinese Journal of Pancreatology

Issue:: 2

DOI:: 10.3760/cma.j.issn.1674-1935.2017.02.001

Key Word:: No keyword available

Abstract：重症急性胰腺炎(SAP)病情危重,死亡率高达10%~20%,是消化内科常见的危急重症[1].急性胰腺炎(AP)是由胰酶激活后引起胰腺组织自身消化所致的急性化学性炎症[2],在治疗过程中常伴随多种并发症的出现,包括全身并发症与局部并发症[3].SAP进展过程中的血液高凝状态(hypercoagulable state)在临床上较为常见,但未引起足够重视.SAP凝血系统的激活可导致弥漫性血管内凝血(disseminated intravascular coagulation, DIC)的发生,进而可能引起局部或全身多器官功能衰竭.2014年《急性胰腺炎诊治指南》以及2015年《中国急性胰腺炎多学科(MDT)诊治共识意见(草案)》中也未对SAP引起的血液高凝状态进行充分的阐述[4-5].本文结合国内外文献及笔者临床实践,对SAP血液高凝状态进行阐述,以提高对该并发症的预防和治疗.

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